1.1: potassium carbonate / acetone / 20 - 25 °C / Industry scale 1.2: 50 - 60 °C 2.1: pyridine / dichloromethane / 5 - 30 °C / Industry scale View Scheme

1.1: potassium carbonate / acetone / 20 - 25 °C / Industry scale 1.2: 50 - 60 °C 2.1: pyridine / dichloromethane / 5 - 30 °C / Industry scale 3.1: water / 75 - 78 °C / Industry scale 4.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 50 - 60 °C 4.2: -70 - -60 °C 4.3: -50 °C 5.1: BH3*S(CH3)2 / tetrahydrofuran / 25 - 50 °C 5.2: 0.5 h / 10 - 15 °C / Industry scale 6.1: raney nickel / methanol / 30 - 35 °C / Autoclave View Scheme

1.1: potassium carbonate / acetone / 20 - 25 °C / Industry scale 1.2: 50 - 60 °C 2.1: pyridine / dichloromethane / 5 - 30 °C / Industry scale 3.1: water / 75 - 78 °C / Industry scale 4.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 50 - 60 °C 4.2: -70 - -60 °C 4.3: -50 °C 5.1: BH3*S(CH3)2 / tetrahydrofuran / 25 - 50 °C 5.2: 0.5 h / 10 - 15 °C / Industry scale 6.1: raney nickel / methanol / 30 - 35 °C / Autoclave 7.1: tetrahydrofuran / 10 - 55 °C 8.1: potassium carbonate / toluene; water / 50 - 55 °C View Scheme

1.1: potassium carbonate / acetone / 20 - 25 °C / Industry scale 1.2: 50 - 60 °C 2.1: pyridine / dichloromethane / 5 - 30 °C / Industry scale 3.1: water / 75 - 78 °C / Industry scale 4.1: ethyl bromide; iodine; magnesium / tetrahydrofuran / 50 - 60 °C 4.2: -70 - -60 °C 4.3: -50 °C 5.1: BH3*S(CH3)2 / tetrahydrofuran / 25 - 50 °C 5.2: 0.5 h / 10 - 15 °C / Industry scale 6.1: raney nickel / methanol / 30 - 35 °C / Autoclave 7.1: tetrahydrofuran / 10 - 55 °C 8.1: potassium carbonate / toluene; water / 50 - 55 °C 9.1: dichloromethane / -25 - -20 °C View Scheme