反应条件
1: NaHCO3 / CH2Cl2 / 0.25 h 2: 4-(aminomethyl)piperidine silica reagent / CH2Cl2 / 0.25 h 3: NaHCO3 / CH2Cl2 / 0.25 h 4: 4-(aminomethyl)piperidine silica reagent / CH2Cl2 / 0.25 h 5: NaHCO3 / CH2Cl2 / 0.25 h 6: 4-(aminomethyl)piperidine silica reagent / CH2Cl2 / 0.25 h 7: NaHCO3 / CH2Cl2 / 0.33 h 8: 58 percent / H2 / Pd/C / ethanol; ethyl acetate / 24 h / 2327.17 Torr / Ambient temperature View Scheme
参考文献
Carpino, Louis A.; Philbin, Michael
Journal of Organic Chemistry, 1999 , vol. 64, # 12 p. 4315 - 4323
