1: 91 percent / TFA / CH2Cl2 / 2 h / Ambient temperature 2: 82 percent / SOCl2 / CH2Cl2 / 2 h / Heating 3: NaHCO3 / CH2Cl2 / 0.25 h 4: 4-(aminomethyl)piperidine silica reagent / CH2Cl2 / 0.25 h 5: NaHCO3 / CH2Cl2 / 0.25 h 6: 4-(aminomethyl)piperidine silica reagent / CH2Cl2 / 0.25 h 7: NaHCO3 / CH2Cl2 / 0.25 h 8: 4-(aminomethyl)piperidine silica reagent / CH2Cl2 / 0.25 h 9: NaHCO3 / CH2Cl2 / 0.33 h 10: 58 percent / H2 / Pd/C / ethanol; ethyl acetate / 24 h / 2327.17 Torr / Ambient temperature View Scheme