3-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈合成路线 （共 12 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=80°C;
参考文献
ALANTOS PHARMACEUTICALS HOLDING, INC.
Patent: WO2008/63671 A2, 2008 ;
Location in patent: Page/Page column 174 ;
WO 2008/063671 A2
反应条件
sodium hydrogencarbonate in chloroform; water T=0 - 20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/134378 A1, 2006 ;
Location in patent: Page/Page column 86 ;
WO 2006/134378 A1
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0°C; 24 h; Heating / reflux;
参考文献
Abbott GmbH and Co. KG
Patent: US7049312 B1, 2006 ;
Location in patent: Page/Page column 117 ;
US 7049312 B1
反应条件
in 1-methyl-pyrrolidin-2-one T=250°C; 20 h;
参考文献
Alantos Pharmaceuticals, Inc.,
Patent: US2006/173183 A1, 2006 ;
Location in patent: Page/Page column 104 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=80°C; 0.25 h; microwave irradiation;
参考文献
Caliendo, Giuseppe; Perissutti, Elisa; Santagada, Vincenzo; Fiorino, Ferdinando; Severino, Beatrice; Cirillo, Donatella; D'Emmanuele Di Villa Bianca, Roberta; Lippolis, Laura; Pinto, Aldo; Sorrentino, Raffaella
European Journal of Medicinal Chemistry, 2004 , vol. 39, # 10 p. 815 - 826
反应条件
ammonium chloride; zinc in methanol T=20°C; 2 h;
参考文献
Ackermann, Jean; Bleicher, Konrad; Ceccarelli Grenz, Simona M.; Chomienne, Odile; Mattei, Patrizio; Schulz-Gasch, Tanja
Patent: US2007/129544 A1, 2007 ;
Location in patent: Page/Page column 56 ;
反应条件
in 1-methyl-pyrrolidin-2-one T=200°C; 4 h; Inert atmosphereMicrowave irradiation;
参考文献
AQUILUS PHARMACEUTICALS, INC.; SUCHOLEIKI, Irving
Patent: WO2014/62204 A1, 2014 ;
Location in patent: Page/Page column 33 ;
反应条件
1: sodium hydrogen carbonate / CHCl3 / 0.2 h / 40 °C / microwave irradiation 2: 95 percent / potassium carbonate / dimethylformamide / 0.25 h / 80 °C / microwave irradiation View Scheme
参考文献
Caliendo, Giuseppe; Grieco, Paolo; Perissutti, Elisa; Santagada, Vincenzo; Santini, Antonello; Albrizio, Stefania; Fattorusso, Caterina; Pinto, Aldo; Sorrentino, Raffaella
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 12 p. 957 - 967
反应条件
1: 84 percent / SnCl2; 37 percent HCl / 3 h / 20 °C 2: sodium carbonate / CHCl3 / 3 h / 20 °C 3: K2CO3 / dimethylformamide / 3 h / 80 °C View Scheme
参考文献
Caliendo, Giuseppe; Grieco, Paolo; Perissutti, Elisa; Santagada, Vincenzo; Santini, Antonello; Albrizio, Stefania; Fattorusso, Caterina; Pinto, Aldo; Sorrentino, Raffaella
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 12 p. 957 - 967
反应条件
in 1-methyl-pyrrolidin-2-one T=250°C; Inert atmosphere;
参考文献
Gege, Christian; Bao, Bagna; Bluhm, Harald; Boer, Juergen; Gallagher, Brian M.; Korniski, Brian; Powers, Timothy S.; Steeneck, Christoph; Taveras, Arthur G.; Baragi, Vijaykumar M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 709 - 716
