3-氧代-3,4-二氢-2H-苯并[b][1,4]噁嗪-6-甲腈合成路线 （共 12 条）
反应条件
chloro-trimethyl-silane Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/134378 A1, 2006 ;
Location in patent: Page/Page column 99-100 ;
WO 2006/134378 A1
反应条件
1: sodium tetrahydroborate; NiII chloride hexahydrate / methanol / 0.33 h / 0 - 5 °C
2: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C
View Scheme
参考文献
Gege, Christian; Bao, Bagna; Bluhm, Harald; Boer, Juergen; Gallagher, Brian M.; Korniski, Brian; Powers, Timothy S.; Steeneck, Christoph; Taveras, Arthur G.; Baragi, Vijaykumar M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 709 - 716
