3-氧-3,4-二氢-2H-1,4-苯并恶嗪-6-羧基 酸合成路线 （共 8 条）
反应条件
1: With sodium hydrogencarbonate in chloroform; water T=0 - 20°C; 48.83 h; 2: With hydrogenchloride in chloroform; water pH=2;
参考文献
Goodman, Krista B.; Neeb, Michael J.; Sehon, Clark A.; Viet, Andrew Q.; Wang, Gren Z.
Patent: US2008/21023 A1, 2008 ;
Location in patent: Page/Page column 122-123 ;
US 20080021023 A1
参考文献
Justus Liebigs Annalen der Chemie, , vol. 311, p. 168
反应条件
potassium carbonate in tetrahydrofuran; water T=20°C; 3 h;
参考文献
TAKEDA CHEMICAL INDUSTRIES, LTD.
Patent: WO2004/46107 A1, 2004 ;
Location in patent: Page 209-210 ;
WO 2004/046107 A1
反应条件
ammonium hydroxide; iron(II) sulfate bei Siedetemperatur;
参考文献
Journal of the American Chemical Society, , vol. 48, p. 464
反应条件
1: potassium carbonate; diluted alcohol 2: diluted natrium carbonate View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 311, p. 168
反应条件
1: benzene 2: potassium carbonate; diluted alcohol 3: diluted natrium carbonate View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 311, p. 168
参考文献
Christiansen
Journal of the American Chemical Society, 1926 , vol. 48, p. 464
反应条件
4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in dichloromethane
T=20°C; 18 h;
参考文献
Goodman, Krista B.; Neeb, Michael J.; Sehon, Clark A.; Viet, Andrew Q.; Wang, Gren Z.
Patent: US2008/21023 A1, 2008 ;
Location in patent: Page/Page column 123 ;
US 20080021023 A1
