反应条件
1: potassium tert-butylate / tert-butyl alcohol / 2 h / 75 °C
2: hydrogenchloride; palladium 10 on activated carbon; hydrogen / tetrahydrofuran / 5 h / 20 °C
3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 °C
4: AlCl3, aluminium chloride / chloroform / 0.5 h / 0 °C
5: sodium tetrahydroborate; sodium hydroxide / water / 72 h / 20 °C
6: triethylsilane; trifluoroacetic acid / 16 h / 20 °C
7: AlCl3, aluminium chloride / toluene / 2 h / Reflux; Inert atmosphere
View Scheme
参考文献
Zhang, Yong-Kang; Plattner, Jacob J.; Freund, Yvonne R.; Easom, Eric E.; Zhou, Yasheen; Ye, Long; Zhou, Huchen; Waterson, David; Gamo, Francisco-Javier; Sanz, Laura M.; Ge, Min; Li, Zhiya; Li, Lingchao; Wang, Hailong; Cui, Han
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1299 - 1307