1,2,4-三甲氧基苯合成路线 （共 122 条）
反应条件
aluminium trichloride
1) ether, reflux, 1h, 2) r.t., 24h;
参考文献
Mahfouz; Hambloch; Omar; Frahm
Archiv der Pharmazie, 1990 , vol. 323, # 3 p. 163 - 169
反应条件
chloroform; chlorine
Erhitzen des erhaltenen oeligen Reaktionsprodukts unter 20 Torr auf 150grad;
参考文献
Oliverio; Castelfranchi; Simonelli
Gazzetta Chimica Italiana, 1952 , vol. 82, p. 109,110 Anm. 3
反应条件
aluminium trichloride in dichloromethane
T=60°C; Friedel-Crafts acylation; 1 h;
参考文献
Cruz; Garduno; Salazar; Martinez; Jimenez-Vazquez; Diaz; Chamorro; Tamariz
Arzneimittel-Forschung/Drug Research, 2001 , vol. 51, # 7 p. 535 - 544
参考文献
Szeki
Chemische Berichte, 1929 , vol. 62, p. 1377
反应条件
1.1: bromine / dichloromethane / 0 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 1 h / -78 °C
3.1: sodium carbonate; palladium on activated charcoal / ethylene glycol dimethyl ether; water / 1 h / 45 °C
4.1: toluene-4-sulfonic acid / methanol; tetrahydrofuran / 1 h / 60 °C
5.1: potassium carbonate / acetone / 20 °C
View Scheme
参考文献
Wang, Guangcheng; Wang, Fang; Cao, Dong; Liu, Yibin; Zhang, Ronghong; Ye, Haoyu; Li, Xiuxia; He, Lin; Yang, Zhuang; Ma, Liang; Peng, Aihua; Xiang, Mingli; Wei, Yuquan; Chen, Lijuan
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 14 p. 3158 - 3163
反应条件
ammonium cerium (IV) nitrate in water; acetonitrile
T=20°C;
参考文献
Love, Brian E.; Bonner-Stewart, Jeffrey; Forrest, Lori A.
Synlett, 2009 , # 5 p. 813 - 817
反应条件
1: With AlCl3, aluminium chloride in 1,2-dichloro-ethane
T=0 - 20°C; Inert atmosphereReflux;
2: With sodium ethanolate in ethanol
3 h; RefluxInert atmosphere;
参考文献
Qu, Da-Hui; Feringa, Ben L.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 6 p. 1107 - 1110
反应条件
pyridine; aluminium trichloride; tetreamethyl ammonium hydroxide
1.) Et2O, RT, 8 h, 2.) H2O, reflux, 36 h; Yield given. Multistep reaction;
参考文献
Lin; Liou; Ko; Teng
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 1 p. 11 - 16
反应条件
1: benzene; AlCl3; HCl / 40 - 50 °C / Zersetzung des Reaktionsgemisches mit Eiswasser
2: sodium propionate / 150 °C
View Scheme
参考文献
Gattermann; Eggers
Chemische Berichte, 1899 , vol. 32, p. 290
反应条件
carbon disulfide; aluminium trichloride
参考文献
Bargellini; Martegiani
Gazzetta Chimica Italiana, 1912 , vol. 42 II, p. 353
