1,2,4-三甲氧基苯合成路线 （共 122 条）
反应条件
hydrogenchloride; zinc(II) chloride in diethyl ether
参考文献
Sanchez-Viesca; Gomez, Maria R.; Berros, Martha
Organic Preparations and Procedures International, 2004 , vol. 36, # 2 p. 135 - 140
反应条件
phosphoric acid; phosphorus pentoxide
参考文献
Anderson et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 598,600
反应条件
trichlorophosphate T=20°C; Vilsmeier reaction; 1 h;
参考文献
Lin, Yung-Lung; Wu, Chung-Shieh; Lin, Shean-Woei; Huang, Jian-Lin; Sun, Yang-Sheng; Yang, Ding-Yah
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 3 p. 685 - 690
反应条件
AlCl3, aluminium chloride in chlorobenzene T=0 - 18°C; 22 h;
参考文献
Kantlehner, Willi; Anders, Ernst; Mezger, Jochen; Stoyanov, Edmont V.; Kress, Ralf; Wermann, Kurt; Frey, Wolfgang; Goerls, Helmar
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2008 , vol. 63, # 4 p. 395 - 406
反应条件
hydrogenchloride; aluminium trichloride; benzene T=40 - 50°C; Zersetzung des Reaktionsgemisches mit Eiswasser;
参考文献
Gattermann; Eggers
Chemische Berichte, 1899 , vol. 32, p. 290
反应条件
1: 1,2,4-trimethoxy benzene With n-butyllithium in diethyl ether; hexane T=-10 - 20°C; Inert atmosphere; 2: boric acid trimethyl ester in diethyl ether; hexane T=-10°C; Inert atmosphere; 3: With water; ammonium chloride in ethyl acetate
参考文献
Alves, Ana P. L.; Junior, Jose Augusto B. C.; Slana, Glaucia B. A.; Cardoso, Jari N.; Wang, Qiang; Lopes, Rosangela S. C.; Lopes, Claudio C.
Synthetic Communications, 2009 , vol. 39, # 20 p. 3693 - 3709
反应条件
1: With n-butyllithium in diethyl ether T=-40 - 20°C; 2: With boric acid trimethyl ester in diethyl ether T=-78 - 20°C; 3: With hydrogenchloride in water; ethyl acetate T=20°C;
参考文献
AMAZENTIS SA; RINSCH, Christopher, L.; BLANCO-BOSE, William; SCHNEIDER, Bernard; MOUCHIROUD, Laurent; RYU, Dongryeol; ANDREUX, Penelope; AUWERX, Johan
Patent: WO2014/4902 A2, 2014 ;
Location in patent: Sheet 29 ;
反应条件
hydrogenchloride; zinc(II) chloride in diethyl ether T=20°C; 15 h;
参考文献
Sanchez-Viesca; Gomez, Maria R.; Berros, Martha
Organic Preparations and Procedures International, 2004 , vol. 36, # 2 p. 135 - 140
反应条件
1.1: nBuLi / tetrahydrofuran / 1 h / -78 °C 1.2: tetrahydrofuran / 16 h / -78 - 20 °C 2.1: 17.5 g / iodobenzene diacetate / H2O; methanol / 18 h / 20 °C View Scheme
参考文献
Davies, Huw M. L.; Dai, Xing; Long, Matthew S.
Journal of the American Chemical Society, 2006 , vol. 128, # 7 p. 2485 - 2490
反应条件
1: AlCl3 / CS2 2: MeONO, HCl 3: aq. H2SO4 View Scheme
参考文献
Hardegger,E. et al.
Helvetica Chimica Acta, 1964 , vol. 47, p. 1996 - 2017
