1,2,4-三甲氧基苯合成路线 （共 122 条）
反应条件
in water T=20 - 25°C; Oxidation; pH=3.0; KineticsEquilibrium constant;
参考文献
Steenken, Steen; Jovanovic, Slobodan V.; Bietti, Massimo; Bernhard, Klaus
Journal of the American Chemical Society, 2000 , vol. 122, # 10 p. 2373 - 2374
反应条件
carbon disulfide; aluminium trichloride
参考文献
Ameer, Farouk; Giles, Robin G. F.; Green, Ivan R.; Pearce, Rene
Synthetic Communications, 2004 , vol. 34, # 7 p. 1247 - 1258
参考文献
Bargellini; Giua
Gazzetta Chimica Italiana, 1912 , vol. 42 I, p. 205
反应条件
1: bromodifluoromethyl phenyl sulphide; 1,3-dimethoxy benzene With titanium tetrachloride in dichloromethane T=20°C; Friedel Crafts type alkylation; 1 h; Inert atmosphere; 2: 1,2,4-trimethoxy benzene in dichloromethane T=20°C; Friedel Crafts type alkylation; 6 h; Inert atmosphere;
参考文献
Kuhakarn, Chutima; Surapanich, Nakin; Kamtonwong, Siriporn; Pohmakotr, Manat; Reutrakul, Vichai
European Journal of Organic Chemistry, 2011 , # 29 p. 5911 - 5918
反应条件
1.1: nBuLi / tetrahydrofuran / 1 h / -78 °C 1.2: tetrahydrofuran / 16 h / -78 - 20 °C 2.1: 17.5 g / iodobenzene diacetate / H2O; methanol / 18 h / 20 °C 3.1: ethanol / 15 h / 20 °C 4.1: 14.10 g / K2CO3 / acetone / 48 h / Heating 5.1: 88 percent / trifluoroacetic acid / CH2Cl2 / 3 h / 20 °C View Scheme
参考文献
Davies, Huw M. L.; Dai, Xing; Long, Matthew S.
Journal of the American Chemical Society, 2006 , vol. 128, # 7 p. 2485 - 2490
反应条件
potassium in toluene T=111°C; 12 h;
参考文献
Dubis, Alina T.; Morzycki, Jacek W.; Poplawski, Janusz
Journal fuer Praktische Chemie (Leipzig), 1991 , vol. 333, # 4 p. 643 - 650
反应条件
1: 98 percent / Br2 / CHCl3 / 0.75 h / 0 °C 2: 82 percent / LDA / tetrahydrofuran / 4 h / -78 °C 3: 70percent aq. perchloric acid / tetrahydrofuran / 1.25 h 4: 80 percent / pyridinium bromide perbromide / tetrahydrofuran / 1 h / 0 deg C to rt View Scheme
参考文献
Clive, Derrick L. J.; Khodabocus, Ahmad; Vernon, Peter G.; Angoh, A. Gaetan; Bordeleau, Luc; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 6 p. 1433 - 1444
反应条件
1: 68 percent / AlCl3 / CH2Cl2 / 1 h / 60 °C 2: 55 percent / NaBH4 / ethanol / 0.5 h / Heating 3: 59 percent / NaOAc; Ac2O / 12 h / Heating View Scheme
参考文献
Cruz; Garduno; Salazar; Martinez; Jimenez-Vazquez; Diaz; Chamorro; Tamariz
Arzneimittel-Forschung/Drug Research, 2001 , vol. 51, # 7 p. 535 - 544
反应条件
2: 75 percent / CsF / dimethylformamide; H2O / 24 h / Heating 3: 78 percent / Ni/Ra / ethanol / 2 h / Heating View Scheme
参考文献
Cabiddu, Salvatore; Contini, Liliana; Fattuoni, Claudia; Floris, Costantino; Gelli, Gioanna
Tetrahedron, 1991 , vol. 47, # 44 p. 9279 - 9288
反应条件
1: 89 percent / AlCl3 / CH2Cl2 / 1 h / 10 °C 2: 94 percent / H2 / 5percent Pd/C / ethanol / 1.5 h / 760 Torr View Scheme
参考文献
Hoegberg, Thomas; Bengtsson, Stefan; Paulis, Tomas de; Johansson, Lars; Stroem, Peter; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1155 - 1163
