(2s,4r)-1,2-二苄氧羰基-4-羟基吡咯烷合成路线 （共 15 条）
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
Giacalone, Francesco; Gruttadauria, Michelangelo; Lo Meo, Paolo; Riela, Serena; Noto, Renato
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2747 - 2760
反应条件
sodium hydrogencarbonate in water; acetone T=20°C;
参考文献
Agarkov, Anton; Greenfield, Scott J.; Ohishi, Takahiro; Collibee, Scott E.; Gilbertson, Scott R.
Journal of Organic Chemistry, 2004 , vol. 69, # 23 p. 8077 - 8085
反应条件
1: chloroformic acid ethyl ester; (2S,4R)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester With triethylamine in tetrahydrofuran T=0°C; 0.5 h; 2: benzyl alcohol in tetrahydrofuran 24 h; Heating;
参考文献
Calderon, Felix; Fernandez, Raquel; Sanchez, Felix; Fernandez-Mayoralas, Alfonso
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 10 p. 1395 - 1403
反应条件
1: (2S,4R)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran T=0°C; 0.5 h; 2: benzyl alcohol in tetrahydrofuran 24 h; Heating; Further stages.;
参考文献
Doyagueez, Elisa G.; Calderon, Felix; Sanchez, Felix; Fernandez-Mayoralas, Alfonso
Journal of Organic Chemistry, 2007 , vol. 72, # 24 p. 9353 - 9356
反应条件
1: NaOH / H2O / 5 h 2: 56 percent / NaHCO3; NaI / dimethylformamide / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 13 p. 5004 - 5007
反应条件
1: NaOH / H2O / 5 h 2: 56 percent / NaHCO3; NaI / dimethylformamide / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 13 p. 5004 - 5007
反应条件
caesium carbonate Ambient temperature;
参考文献
Bardaji, Eduard; Torres, Joseph L.; Clapes, Pere; Albericio, Fernando; Barany, George; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 7 p. 1755 - 1760
反应条件
in methanol 8 h; Ambient temperature;
参考文献
Barrett, Anthony G. M.; Pilipauskas, Daniel
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2787 - 2800
反应条件
1: 1.) EtO2CN=NCOOEt, Ph3P, 2.) aq. NaOH / 1.) HCO2H, THF, from 0 deg C to r.t., 18 h; 2.) 1,4-dioxane, 0 deg C, 0.25 h 2: 68 percent / H2 / Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature View Scheme
参考文献
Brown, Allan G.; Moss, Stephen F.; Southgate, Robert
Tetrahedron Letters, 1994 , vol. 35, # 3 p. 451 - 454
反应条件
1: With formic acid; triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=0 - 20°C; Mitsunobu reaction; 18 h; 2: With sodium hydroxide in 1,4-dioxane T=0°C; 0.25 h; Further stages.;
参考文献
Huang, Junmin; Zhang, Xiaotong; Armstrong, Daniel W.
Angewandte Chemie - International Edition, 2007 , vol. 46, # 47 p. 9073 - 9077
