2-(4-甲氧基苯氨基)-苯甲酸合成路线 （共 21 条）
参考文献
Sterling Drug Inc.
Patent: US4515980 A1, 1985 ;
反应条件
1: phosphorus (V)-chloride; benzene 2: sodium-amalgam; ethanol; sodium hydrogencarbonate 3: iron (III)-chloride; hydrochloric acid; water View Scheme
参考文献
Scherlin et al.
Zhurnal Obshchei Khimii, 1938 , vol. 8, p. 884,887
Chem. Zentralbl., 1939 , vol. 110, # I p. 4324
反应条件
1: POCl3 / 2 h / Heating 2: 0.08 h / 70 °C 3: 1.03 g / (NH4)2CO3, phenol / 0.75 h / 120 °C View Scheme
参考文献
Tomosaka, Hideyuki; Anzai, Kentaro; Hasegawa, Eietsu; Horigome, Tsuneyoshi; Omata, Saburo
Bioscience, Biotechnology and Biochemistry, 1996 , vol. 60, # 4 p. 714 - 716
参考文献
Itier,J.; Casadevall,A.
Bulletin de la Societe Chimique de France, 1969 , p. 2342 - 2355
反应条件
trichlorophosphate 6 h; Heating;
参考文献
Csuk, Rene; Barthel, Alexander; Raschke, Christian
Tetrahedron, 2004 , vol. 60, # 27 p. 5737 - 5750
反应条件
copper in ethanol
T=110°C; Ullmann's reaction; 4 h;
参考文献
Tuan Lormier, Anh; Boyer, Gerard; Faure, Robert; Pierre Galy, Jean
Heterocycles, 2002 , vol. 57, # 3 p. 449 - 463
反应条件
pyridine; copper; potassium carbonate in water
Ullmann-Goldberg reaction; 0.333333 h; sonication;
参考文献
Docampo Palacios, Maite L.; Pellon Comdom, Rolando F.
Synthetic Communications, 2003 , vol. 33, # 10 p. 1771 - 1775
反应条件
1: With potassium hydroxide in ethanol; water
3 h; Inert atmosphereReflux;
2: With hydrogenchloride in ethanol; water
pH=2; Inert atmosphere;
参考文献
Neukom, Joshua D.; Aquino, Alvin S.; Wolfe, John P.
Organic Letters, 2011 , vol. 13, # 9 p. 2196 - 2199
反应条件
potassium carbonate; CuPy2Cl2
T=75°C; 0.333333 h; microwave irradiation;
参考文献
Maradolla, Mohan Babu; Mandha, Amaravathi; Garimella, Chandra Mouli
Journal of Chemical Research, 2007 , # 10 p. 587 - 589
反应条件
copper(l) iodide; potassium carbonate; L-proline in 3-methyl-1-butanol
T=140°C; 1 h; Microwave irradiation;
参考文献
Marques, Emerson F.; Bueno, Mauro A.; Duarte, Patricia D.; Silva, Larissa R.S.P.; Martinelli, Ariani M.; Dos Santos, Caio Y.; Severino, Richele P.; Broemme, Dieter; Vieira, Paulo C.; Correa, Arlene G.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 10 - 21
