2-(4-甲氧基苯氨基)-苯甲酸合成路线 （共 21 条）
反应条件
1: With LiNH2
1 h; Inert atmosphere;
2: With hydrogenchloride in water
Inert atmosphere;
参考文献
Davis, Edward M.; Nanninga, Thomas N.; Tjiong, Howie I.; Winkle, Derick D.
Organic Process Research and Development, 2005 , vol. 9, # 6 p. 843 - 846
反应条件
hydrogenchloride; potassium carbonate in N-methyl-acetamide; water
参考文献
Sterling Drug Inc.
Patent: US4510139 A1, 1985 ;
反应条件
sodium carbonate; acetic acid in sodium hydroxide; water; ethylene glycol
参考文献
Smith, John Anthony; West, Richard Martin
Patent: US2004/191792 A1, 2004 ;
反应条件
pyridine; copper; potassium carbonate in pentan-1-ol
Ullmann-Jourdan reactions; 5 h; Heating;
参考文献
Csuk, Rene; Barthel, Alexander; Raschke, Christian
Tetrahedron, 2004 , vol. 60, # 27 p. 5737 - 5750
反应条件
1.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene / 20 - 120 °C / Inert atmosphere
2.1: potassium hydroxide / ethanol; water / 20 - 100 °C / Inert atmosphere
2.2: 0 °C / pH 2 / Inert atmosphere
View Scheme
参考文献
Adeniji, Adegoke O.; Twenter, Barry M.; Byrns, Michael C.; Jin, Yi; Chen, Mo; Winkler, Jeffrey D.; Penning, Trevor M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2311 - 2323
参考文献
Drosdow
Zhurnal Obshchei Khimii, 1938 , vol. 8, p. 937,941
Chem. Zentralbl., 1939 , vol. 110, # I p. 4326
反应条件
1: 260 °C
2: iodine; sulfur
View Scheme
参考文献
Baltzly et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 2673,2677
反应条件
1: POCl3 / 2 h / Heating
2: 0.08 h / 70 °C
3: 1.03 g / (NH4)2CO3, phenol / 0.75 h / 120 °C
4: 86.9 percent / HBr, H2O / 3 h / Heating
View Scheme
参考文献
Tomosaka, Hideyuki; Anzai, Kentaro; Hasegawa, Eietsu; Horigome, Tsuneyoshi; Omata, Saburo
Bioscience, Biotechnology and Biochemistry, 1996 , vol. 60, # 4 p. 714 - 716
参考文献
Radadiya; Purohit; Patolia
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 5 p. 1112 - 1114
反应条件
1: phosphorus (V)-chloride; benzene / und Erwaermen des Reaktionsgemisches mit Aluminiumchlorid
2: sodium-amalgam; ethanol; sodium hydrogencarbonate
3: hydrochloric acid; iron (III)-chloride; water
View Scheme
参考文献
Scherlin et al.
Zhurnal Obshchei Khimii, 1938 , vol. 8, p. 884,887
Chem. Zentralbl., 1939 , vol. 110, # I p. 4324
