(2S,4S)-1-(苄基羰基)-4-羟基吡咯烷-2-羧酸合成路线 （共 20 条）
反应条件
sodium hydrogencarbonate 3 h; from 0 deg C to r.t.;
参考文献
Brown, Allan G.; Moss, Stephen F.; Southgate, Robert
Tetrahedron Letters, 1994 , vol. 35, # 3 p. 451 - 454
反应条件
sodium hydroxide in tetrahydrofuran T=25°C; 0.5 h;
参考文献
Seki, Masahiko; Matsumoto, Kazuo
Bioscience, Biotechnology, and Biochemistry, 1995 , vol. 59, # 6 p. 1161 - 1162
反应条件
1: With triphenylphosphine; diethylazodicarboxylate in dichloromethane T=20°C; Isomerization; 2 h; 2: With sodium hydroxide in methanol; water T=0°C; Hydrolysis; 0.5 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 72, # 12 p. 2737 - 2754
反应条件
1: 635 g / aq. NaHCO3 / tetrahydrofuran / 17 h / 25 °C 2: 90 percent / SOCl2 / 17 h / 25 °C 3: 1.) DCC, CuCl / 1.) dioxane, 45-50 deg C, 48 h, 2.) toluene, reflux, 24 h 4: 92 percent / aq. NaOH / tetrahydrofuran / 0.5 h / 25 °C View Scheme
参考文献
Bioscience, Biotechnology, and Biochemistry, , vol. 59, # 6 p. 1161 - 1162
反应条件
methanol; sodium tetrahydroborate
参考文献
Journal of the American Chemical Society, , vol. 79, p. 185,190
反应条件
1: 635 g / aq. NaHCO3 / tetrahydrofuran / 17 h / 25 °C 2: 90 percent / SOCl2 / 17 h / 25 °C 3: 1.) DCC, CuCl / 1.) dioxane, 45-50 deg C, 48 h, 2.) toluene, reflux, 24 h 4: 92 percent / aq. NaOH / tetrahydrofuran / 0.5 h / 25 °C View Scheme
参考文献
Bioscience, Biotechnology, and Biochemistry, , vol. 59, # 6 p. 1161 - 1162
反应条件
1: 68 percent / H2 / Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature 2: 81 percent / aqueous NaHCO3 / 3 h / from 0 deg C to r.t. View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 3 p. 451 - 454
反应条件
1: 1.) EtO2CN=NCOOEt, Ph3P, 2.) aq. NaOH / 1.) HCO2H, THF, from 0 deg C to r.t., 18 h; 2.) 1,4-dioxane, 0 deg C, 0.25 h 2: 68 percent / H2 / Pd/C / ethanol / 2 h / 760 Torr / Ambient temperature 3: 81 percent / aqueous NaHCO3 / 3 h / from 0 deg C to r.t. View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 3 p. 451 - 454
反应条件
1: With sodium hydroxide; methanesulfonyl chloride in CPME; water T=80 - 105°C; 4 - 6 h; 2: With sodium hydroxide in CPME; water T=20 - 65°C; 2 - 8 h;
参考文献
JP2005/112761 A, ;
Page/Page column 8 ;
反应条件
sodium chlorite; sodium dihydrogenphosphate; water in methyl-2-butene; tert-butyl alcohol T=0 - 20°C; 1.5 h;
参考文献
Mereyala, Hari Babu; Pathuri, Gopal; Nagarapu, Lingaiah
Synthetic Communications, 2012 , vol. 42, # 9 p. 1278 - 1287
