N-BOC-反式-4-羟基-D-脯氨酸甲酯合成路线 （共 27 条）
反应条件
1: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 2: 88.7 percent / dimethylsulfoxide / 90 °C 3: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
potassium carbonate in methanol
参考文献
Zhang, Xiaojun; Schmitt, Aaron C.; Jiang, Wen
Tetrahedron Letters, 2001 , vol. 42, # 32 p. 5335 - 5338
反应条件
sodium azide in methanol T=45°C;
参考文献
Mioskowski, Charles; Marin, Sandra De Lamo; Maruani, Martine; Gill, Manjinder
Patent: US2006/199853 A1, 2006 ;
Location in patent: Page/Page column 47 ;
反应条件
sodium hydrogencarbonate in methanol T=20°C; Inert atmosphere;
参考文献
Jing, Qing; Li, Huiying; Roman, Linda J.; Martasek, Pavel; Poulos, Thomas L.; Silverman, Richard B.
ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 56 - 60
反应条件
sodium methylate in methanol
参考文献
Jordan, Stephan; Schwemler, Christoph; Kosch, Winfried; Kretschmer, Axel; Schwenner, Eckhardt; Stropp, Udo; Mielke, Burkhard
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 6 p. 681 - 686
参考文献
Shionogi Seiyaku Kabushiki Kaisha
Patent: US5317016 A1, 1994 ;
反应条件
sodium azide T=45°C;
参考文献
Chapal, Nicolas; McNicol, Patricia; Jette, Lucie
Patent: US2006/223884 A1, 2006 ;
Location in patent: Page/Page column 60 ;
反应条件
potassium carbonate in acetone T=20°C;
参考文献
Chuan, Yongming; Chen, Guihua; Peng, Yungui
Tetrahedron Letters, 2009 , vol. 50, # 25 p. 3054 - 3058
反应条件
potassium carbonate in methanol T=20°C; 1 h;
参考文献
Marusawa, Hiroshi; Setoi, Hiroyuki; Sawada, Akihiko; Kuroda, Akio; Seki, Jiro; Motoyama, Yukio; Tanaka, Hirokazu
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1399 - 1415
参考文献
Gomez-Vidal, Jose A.; Silverman, Richard B.
Organic Letters, 2001 , vol. 3, # 16 p. 2481 - 2484
