N-BOC-反式-4-羟基-D-脯氨酸甲酯合成路线 （共 27 条）
反应条件
1: 97 percent / triphenylphosphine; DIAD / tetrahydrofuran / 20 h / 20 °C 2: 98 percent / sodium azide / 5 h / 40 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 5 p. 1928 - 1938
反应条件
1: With potassium hydrogencarbonate in 1,4-dioxane 14 h; 2: With diethylamino-sulfur trifluoride in dichloromethane T=-78 - 20°C; 20.75 h;
参考文献
Hodgest, Jonathan A.; Raines, Ronald T.
Journal of the American Chemical Society, 2003 , vol. 125, # 31 p. 9262 - 9263
反应条件
sodium hydroxide in methanol 0.333333 h;
参考文献
Iso; Irie; Iwaki; Kii; Sendo; Motokawa; Nishitani
Journal of Antibiotics, 1996 , vol. 49, # 5 p. 478 - 484
反应条件
1: 95 percent / aq. NaOH / tetrahydrofuran / 0 °C 2: 65 percent / DEAD; PPh3; THF / 0 - 20 °C 3: 80 percent / Amberlyst-15(R) / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 3 p. 803 - 806
反应条件
in methanol; diethyl ether
参考文献
Torino, Domenica; Mollica, Adriano; Pinnen, Francesco; Feliciani, Federica; Spisani, Susanna; Lucente, Gino
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 251 - 259
反应条件
1: 95 percent / aq. NaOH / tetrahydrofuran / 0 °C 2: 65 percent / DEAD; PPh3; THF / 0 - 20 °C 3: 80 percent / Amberlyst-15(R) / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 3 p. 803 - 806
反应条件
1: Et3N / ethyl acetate / 15 h / 0 - 20 °C 2: DIAD; PPh3 / tetrahydrofuran / 1 h / 0 - 20 °C 3: 1N aq. NaOH / methanol / 1 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 4 p. 587 - 590
反应条件
1: With sodium hydroxide; water in tetrahydrofuran T=0°C; 2: With triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=0 - 20°C; Mitsunobu reaction; 3: With amberlyst-15(R) in methanol T=20°C;
参考文献
Tetrahedron Letters, , vol. 44, # 42 p. 7809 - 7812
反应条件
1: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 2: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 3: 88.7 percent / dimethylsulfoxide / 90 °C 4: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: 97 percent / NaBH4 / methanol; H2O / 15 h / 4 °C 2: 63 percent / methanol; diethyl ether View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 7 p. 2253 - 2265
