3-[(1S)-1-氨基乙基]-8-氯-2-苯基-1(2H)-异喹啉酮合成路线 （共 2 条）
反应条件
1.1: triethylamine / butan-1-ol / 16 h / Reflux 2.1: hydrogenchloride; water / ethanol / 1 h / 20 °C 2.2: pH 8 - 9 View Scheme
参考文献
INTELLIKINE, INC.; INFINITY PHARMACEUTICALS, INC.; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; CASTRO, Alfredo, C.; EVANS, Catherine, A.
Patent: WO2011/146882 A1, 2011 ;
WO 2011/146882 A1
反应条件
1.1: triethylamine / isopropyl alcohol / 24 h / 80 °C 2.1: hydrogenchloride / ethanol; water / 1.5 h / 22 - 35 °C 2.2: pH 8 - 9 View Scheme
参考文献
Ren, Pingda; Martin, Michael; Isbester, Paul; Lane, Benjamin S.; Kropp, Jason
Patent: US2012/184568 A1, 2012 ;
