(R)-N-Boc-2-羟甲基吗啉合成路线 （共 14 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=70°C; 9 h;
参考文献
Yanagisawa, Hiroaki; Kanazaki, Takuro
Heterocycles, 1993 , vol. 35, # 1 p. 105 - 109
反应条件
triethylamine in dichloromethane T=20°C; 16 h;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2009/44162 A1, 2009 ;
Location in patent: Page/Page column 263-264 ;
WO 2009/044162 A1
反应条件
1: {(2R)-4-[(4-methylphenyl)sulfonyl]-2-morpholinyl}methanol With naphthalene; sodium in tetrahydrofuran T=0°C; 0.0833333 h; 2: With hydrogenchloride in tetrahydrofuran; water 3: di-tert-butyl dicarbonate With sodium hydroxide; sodium hydrogencarbonate in 1,4-dioxane; water T=20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/30366 A1, 2007 ;
Location in patent: Page/Page column 107 ;
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 0.416667 h; 2: With methanol; acetic acid in tetrahydrofuran
参考文献
WO2008/121685 A1, ;
Page/Page column 39-40 ;
WO 2008/121685 A1
反应条件
1: 88 percent / Et3N / CH2Cl2 / 2 h / 20 - 25 °C 2: 100 percent / H2 / 5percent Pd/C / ethanol / 9 h / 70 °C View Scheme
参考文献
Heterocycles, , vol. 35, # 1 p. 105 - 109
反应条件
1.1: triethylamine / dichloromethane / 5 h / 0 - 20 °C 2.1: sodium hydride / hexane; tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C 2.2: 20 °C 2.3: 0 °C 3.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 144 h / 760.05 Torr 4.1: naphthalene; sodium / tetrahydrofuran / 0.08 h / 0 °C View Scheme
反应条件
1.1: sodium hydride / hexane; tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C 1.2: 20 °C 1.3: 0 °C 2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 144 h / 760.05 Torr 3.1: naphthalene; sodium / tetrahydrofuran / 0.08 h / 0 °C View Scheme
反应条件
1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 144 h / 760.05 Torr 2: naphthalene; sodium / tetrahydrofuran / 0.08 h / 0 °C View Scheme
反应条件
1: potassium carbonate / water; acetone / 0.5 h / 0 - 20 °C 2: palladium on carbon; hydrogen / methanol / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 16 p. 4836 - 4843
反应条件
Dess-Martin periodane in dichloromethane T=0 - 20°C; 2 h;
参考文献
Cumming, John G.; Bower, Justin F.; Waterson, David; Faull, Alan; Poyser, Philip J.; Turner, Paul; McDermott, Benjamin; Campbell, Andrew D.; Hudson, Julian; James, Michael; Winter, Jon; Wood, Christine
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 3895 - 3899
