(R)-N-Boc-2-羟甲基吗啉合成路线 （共 14 条）
反应条件
1: With sodium hydrogencarbonate in water; acetone T=0°C; 2: With 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; trichloroisocyanuric acid; sodium bromide in water; acetone T=0 - 20°C; 0.333333 h; 3: With hydrogenchloride; sodium carbonate more than 3 stages;
参考文献
SMITHKLINE BEECHAM CORPORATION; VITAE PHARMACEUTICALS, INC.
Patent: WO2008/124575 A1, 2008 ;
Location in patent: Page/Page column 112; 114 ;
WO 2008/124575 A1
反应条件
1.1: triethylamine / toluene / 3 °C / Inert atmosphere 1.2: 2.5 h / 3 - 15 °C / Inert atmosphere 2.1: tetrabutylammomium bromide / toluene / 4 h / 20 - 108 °C 3.1: ethanolamine / 2-methyl tetrahydrofuran / 22 h / 25 - 40 °C / Inert atmosphere View Scheme
参考文献
ASTRAZENECA AB; CANTIN, Louis-David; LUO, Xuehong; TOMASZEWSKI, Miroslaw, Jerzy
Patent: WO2011/62550 A1, 2011 ;
WO 2011/062550 A1
反应条件
polymer supported triphenylphosphine; carbon tetrabromide in dichloromethane
T=20°C; 4 h;
参考文献
MEDIVIR AB
Patent: WO2007/6714 A1, 2007 ;
Location in patent: Page/Page column 121 ;
