(S)-N-Boc-2-羟甲基吗啉合成路线 （共 14 条）
反应条件
hydrogenchloride; hydrogen; 1 Pd/C in ethanol; water T=70°C;
参考文献
Jiangsu Hengrui Medicine Co. Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.
Patent: US2010/210640 A1, 2010 ;
Location in patent: Page/Page column 13 ;
US 20100210640 A1
反应条件
triethylamine in dichloromethane T=20°C; 16 h;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2009/44162 A1, 2009 ;
Location in patent: Page/Page column 259 ;
WO 2009/044162 A1
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; 3 h;
参考文献
WO2007/6715 A1, ;
Page/Page column 38-39 ;
WO 2007/006715 A1
反应条件
diborane in tetrahydrofuran 2.5 h; Reflux;
参考文献
US2013/289020 A1, ;
Paragraph 0368; 0369 ;
反应条件
1: red-Al / tetrahydrofuran 2: NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 2 p. 533 - 537
反应条件
1: t-BuOK / 2-methyl-butan-2-ol 2: red-Al / tetrahydrofuran 3: NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 2 p. 533 - 537
反应条件
1: H2 / 10percent Pd/C / methanol / 8 h / 60 °C 2: Et3N / methanol View Scheme
参考文献
Heterocycles, , vol. 35, # 1 p. 105 - 109
反应条件
1: 100 percent / 20percent aq. CH3COOH / 1 h / 90 °C 2: 88 percent / NaOEt / ethanol / 1 h / 20 - 25 °C 3: 100 percent / LiAlH4 / tetrahydrofuran / 4 h / 60 °C 4: H2 / 10percent Pd/C / methanol / 8 h / 60 °C 5: Et3N / methanol View Scheme
参考文献
Heterocycles, , vol. 35, # 1 p. 105 - 109
反应条件
1: 100 percent / LiAlH4 / tetrahydrofuran / 4 h / 60 °C 2: H2 / 10percent Pd/C / methanol / 8 h / 60 °C 3: Et3N / methanol View Scheme
参考文献
Heterocycles, , vol. 35, # 1 p. 105 - 109
反应条件
1: 88 percent / NaOEt / ethanol / 1 h / 20 - 25 °C 2: 100 percent / LiAlH4 / tetrahydrofuran / 4 h / 60 °C 3: H2 / 10percent Pd/C / methanol / 8 h / 60 °C 4: Et3N / methanol View Scheme
参考文献
Heterocycles, , vol. 35, # 1 p. 105 - 109
