(S)-N-Boc-2-羟甲基吗啉合成路线 （共 14 条）
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; sodium hydrogencarbonate in ethyl acetate T=-5°C; 2 h;
参考文献
MOLECULAR NEUROIMAGING, LLC
Patent: WO2007/5935 A2, 2007 ;
Location in patent: Page/Page column 52; 53 ;
WO 2007/005935 A2
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; tetrabutyl-ammonium chloride; potassium bromide
参考文献
Fish, Paul Vincent; MacKenny, Malcolm Christian; Stobie, Alan; Wakenhut, Florian; Whitlock, Gavin Alistair
Patent: US2005/250775 A1, 2005 ;
Location in patent: Page/Page column 45 ;
US 20050250775 A1
反应条件
1: triethylamine / dichloromethane / 1.5 h / 0 - 20 °C 2: N,N-dimethyl-formamide / 16 h / 110 - 115 °C 3: ethanolamine / 16 h / 20 °C View Scheme
参考文献
ASTRAZENECA AB; CANTIN, Louis-David; MARTINO, John; TOMASZEWSKI, Miroslaw; YU, Xiao Hong
Patent: WO2012/158117 A1, 2012 ;
WO 2012/158117 A1
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=0 - 20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/121685 A1, 2008 ;
Location in patent: Page/Page column 44 ;
WO 2008/121685 A1
