4-苄基-2-吗啉甲酸盐酸盐合成路线 （共 5 条）
反应条件
hydrogenchloride in water T=-10°C; 2.5 h; Reflux;
参考文献
HYUNDAI PHARM CO., LTD.; LEE, In Hee; PARK, Chang Min; KIM, Se Hoan; CHAE, Hee Il; PYEON, Doo Hyeok; SHIN, Myoung Hyeon; HWANG, Jeong Un; MOON, Soon Young; HA, Tae Young; KIM, So Youn; CHOI, Hyuk Joon; YOO, Myoung Hyun; LEE, Jong Chan; KIM, Young Seok; RHEE, Jae Keol
Patent: WO2012/128582 A2, 2012 ;
Location in patent: Page/Page column 28 ;
WO 2012/128582 A2
反应条件
1.1: toluene / 12 h / 20 °C 1.2: 0.83 h / -5 °C 2.1: hydrogenchloride / water / 2.5 h / -10 °C / Reflux View Scheme
参考文献
WO2012/128582 A2, ;
WO 2012/128582 A2
反应条件
1: sulfuric acid / 12 h / Reflux 2: t-BuOMe-H2O / 12 h View Scheme
参考文献
WO2012/128582 A2, ;
WO 2012/128582 A2
反应条件
sulfuric acid 12 h; Reflux;
参考文献
HYUNDAI PHARM CO., LTD.; LEE, In Hee; PARK, Chang Min; KIM, Se Hoan; CHAE, Hee Il; PYEON, Doo Hyeok; SHIN, Myoung Hyeon; HWANG, Jeong Un; MOON, Soon Young; HA, Tae Young; KIM, So Youn; CHOI, Hyuk Joon; YOO, Myoung Hyun; LEE, Jong Chan; KIM, Young Seok; RHEE, Jae Keol
Patent: WO2012/128582 A2, 2012 ;
Location in patent: Page/Page column 113 ;
WO 2012/128582 A2
反应条件
1.1: oxalyl dichloride / N,N-dimethyl-formamide / 1,2-dichloro-ethane / 3 h / 65 °C 1.2: 4 h / 0 - 20 °C 2.1: ammonium formate / palladium-on-charcoal / ethanol / 2 h / 50 °C View Scheme
参考文献
ArQuele, Inc.
Patent: US2012/329791 A1, 2012 ;
