4-苄基-2-吗啉甲酸乙酯合成路线 （共 5 条）
反应条件
1: With sulfuric acid T=20 - 65°C; 66 h; Heating / reflux; 2: With potassium carbonate in water Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/60949 A2, 2005 ;
Location in patent: Page/Page column 276 ;
WO 2005/060949 A2
反应条件
1: diethyl ether / 120 h / Ambient temperature 2: KOBu-t / 1,2-dimethoxy-ethane / 1.) 0 deg C, 2 h, 2.) reflux, 1 h 3: 79 percent / concd. H2SO4 / 48 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 6 p. 683 - 689
反应条件
1: KOBu-t / 1,2-dimethoxy-ethane / 1.) 0 deg C, 2 h, 2.) reflux, 1 h 2: 79 percent / concd. H2SO4 / 48 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 6 p. 683 - 689
反应条件
1-methyl-1,4-cyclo-hexadiene; palladium 10 on activated carbon in ethanol T=88°C; 34 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/74291 A1, 2004 ;
Location in patent: Page 66-67 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol T=25°C; 4 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/16084 A1, 2009 ;
Location in patent: Page/Page column 47 ;
WO 2009/016084 A1
