1,3,4-三甲基尿嘧啶合成路线 （共 42 条）
反应条件
4-(N,N-dimethlyamino)pyridine; acetic anhydride in pyridine
参考文献
NOVARTIS AG; AHMED, Mahbub; ASHALL-KELLY, Alexander; BLOOMFIELD, Graham Charles; GUERITZ, Louisa; MCKENNA, Jeffrey; MCKENNA, Joseph; MUTTON, Simon; PARMAR, Rakesh; SHEPERD, Jon; WRIGHT, Paul
Patent: US2014/171412 A1, 2014 ;
Location in patent: Page/Page column ;
反应条件
sodium hydroxide
T=90°C;
参考文献
Hirota, Kosaku; Abe, Yoshio; Asao, Tetsuji; Senda, Shigeo; Kitade, Yukio; Maki, Yoshifumi
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 985 - 990
参考文献
Behrend; Fricke
Justus Liebigs Annalen der Chemie, 1903 , vol. 327, p. 267
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Behrend; Dietrich
Justus Liebigs Annalen der Chemie, 1899 , vol. 309, p. 278
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Behrend; Hoffmann
Justus Liebigs Annalen der Chemie, 1889 , vol. 253, p. 74
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Behrend
Justus Liebigs Annalen der Chemie, 1885 , vol. 231, p. 249
Justus Liebigs Annalen der Chemie, 1885 , vol. 229, p. 17
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Hagen
Justus Liebigs Annalen der Chemie, 1888 , vol. 244, p. 15
反应条件
tetra(n-butyl)ammonium hydrogensulfate in N,N-dimethyl-formamide
T=30 - 40°C; 30 h;
参考文献
Kumar, Subodh; Chimni, Swapandeep Singh
Journal of Chemical Research, Miniprint, 1992 , # 1 p. 343 - 359
反应条件
sodium hydroxide
40 h; Heating;
参考文献
Grahner; Winiwarter; Lanzner; Muller
Journal of Medicinal Chemistry, 1994 , vol. 37, # 10 p. 1526 - 1534
反应条件
tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate in N,N-dimethyl-formamide
T=30 - 40°C;
参考文献
Kumar, Subodh; Chimni, Swapandeep Singh
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994 , vol. 33, # 2 p. 179 - 181
反应条件
hydrogen bromide
1 h; Reflux;
参考文献
Sajiki, Hironao; Iida, Yusuke; Ikawa, Kanoko; Sawama, Yoshinari; Monguchi, Yasunari; Kitade, Yukio; Maki, Yoshifumi; Inoue, Hideo; Hirota, Kosaku
Molecules, 2012 , vol. 17, # 6 p. 6519 - 6546
反应条件
1.1: sodium hydride / tetrahydrofuran / 3 h / Heating
1.2: 51 percent / tetrahydrofuran / 18 h / 20 °C
2.1: 92 percent / Raney nickel / H2O; ethanol / 0.5 h / 20 °C
View Scheme
参考文献
Norris, Peter; Shechter, Harold
Journal of Organic Chemistry, 1999 , vol. 64, # 20 p. 7290 - 7298
反应条件
sodium hydroxide in ethanol
T=25°C;
参考文献
Esteve, Cristina; Nueda, Arsenio; Diaz, Jose Luis; Beleta, Jorge; Cardenas, Alvaro; Lozoya, Estrella; Cadavid, Maria Isabel; Loza, Maria Isabel; Ryder, Hamish; Vidal, Bernat
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 14 p. 3642 - 3645
反应条件
zinc(II) chloride in tetrahydrofuran; diethyl ether
T=0 - 20°C; 3 h; Overall yield = 51 percent;
参考文献
Shih, Yu-Chiao; Yang, Ya-Ying; Lin, Chun-Chi; Chien, Tun-Cheng
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4027 - 4036
