alpha-丁基-N-甲基苄胺合成路线 (共 4 条)
反应条件
1: N-methyl-benzamide With 2-fluoro-pyridine; trifluoromethylsulfonic anhydride in dichloromethane T=-78 - 0°C; Inert atmosphere; 2: n-butyl-magnesium bromide With cerium(III) chloride heptahydrate in tetrahydrofuran; dichloromethane T=-78°C; 1 h; Inert atmosphere; 3: With sodium tetrahydroborate in tetrahydrofuran; methanol; dichloromethane T=20°C; 3 h; Inert atmosphere;
参考文献
Xiao, Kai-Jiong; Wang, Ai-E; Huang, Pei-Qiang
Angewandte Chemie - International Edition, 2012 , vol. 51, # 33 p. 8314 - 8317
反应条件
strontium in tetrahydrofuran T=20°C; Barbier-type alkylation; 2 h;
参考文献
Miyoshi, Norikazu; Ikehara, Daitetsu; Kohno, Tadashi; Matsui, Aki; Wada, Makoto
Chemistry Letters, 2005 , vol. 34, # 6 p. 760 - 761
反应条件
in tetrahydrofuran T=-60°C; 3 h;
参考文献
Bozec-Ogor; Salou-Guiziou; Yaouanc; Handel
Tetrahedron Letters, 1995 , vol. 36, # 34 p. 6063 - 6066
参考文献
Lutz et al.
Journal of Organic Chemistry, 1947 , vol. 12, p. 760,761, 763