2-甲基-6-[双(叔丁氧基羰基)氨基]-4-氯嘧啶合成路线 （共 2 条）
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran T=20°C; 3 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong
Patent: WO2012/35039 A1, 2012 ;
Location in patent: Page/Page column 144 ;
WO 2012/035039 A1
反应条件
1: With lithium hexamethyldisilazane in tetrahydrofuran T=0°C; 0.25 h; 2: With di-tert-butyl dicarbonate T=20°C; 18 h;
参考文献
F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; GOODACRE, Simon; LAI, Yingjie; LIANG, Yun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong
Patent: WO2012/66061 A1, 2012 ;
Location in patent: Page/Page column 113-114 ;
WO 2012/066061 A1
