3-氯-2,2-二甲基丙酸合成路线 （共 26 条）
反应条件
1: 72 percent / KF / dimethylformamide / 12 h / 120 - 130 °C
2: 1.) SOCl2 / 1.) 80 deg C, 2 h, 2.) CH2Cl2, -10 deg C -5 deg C, water, then 2 h, 0 deg C
3: 71 percent / cuprous bromide / benzene / 6 h / Heating
View Scheme
参考文献
Beckwith; Easton
Tetrahedron, 1983 , vol. 39, # 23 p. 3995 - 4001
反应条件
1: thionyl chloride
2: triphenylphosphine
3: 70 percent / PhI(OAc)2; I2 / Pd(OAc)2 / CH2Cl2 / 48 h / 65 °C
View Scheme
参考文献
Giri, Ramesh; Wasa, Masayuki; Breazzano, Steven P.; Yu, Jin-Quan
Organic Letters, 2006 , vol. 8, # 25 p. 5685 - 5688
反应条件
1: 89 percent / Na2CO3, Na2S / H2O / 45 °C
2: 92 percent / conc. H2SO4 / benzene / 24 h / Heating
3: Na / toluene
View Scheme
参考文献
King, Mathias; Baati, Rachid; Wagner, Alain
Chemical Communications, 2012 , vol. 48, # 74 p. 9308 - 9309
反应条件
1: thionyl chloride
2: triphenylphosphine
View Scheme
参考文献
Giri, Ramesh; Wasa, Masayuki; Breazzano, Steven P.; Yu, Jin-Quan
Organic Letters, 2006 , vol. 8, # 25 p. 5685 - 5688
反应条件
1: sodium ethylate; ethanol / beim Erwaermen des Reaktionsgemisches mit Natrium-methanthiolat in Aethanol
2: acetic acid; aqueous hydrogen peroxide
View Scheme
参考文献
Truce; Knospe
Journal of the American Chemical Society, 1955 , vol. 77, p. 5063,5067
反应条件
1: sodium ethylate; ethanol / beim Erwaermen des Reaktionsgemisches mit Natrium-methanthiolat in Aethanol
2: acetic acid; aqueous hydrogen peroxide
3: toluene-4-sulfonic acid
4: sodium ethylate; benzene
View Scheme
参考文献
Truce; Knospe
Journal of the American Chemical Society, 1955 , vol. 77, p. 5063,5067
