N-(三苯基甲基)-DL-丝氨酸甲酯合成路线 （共 10 条）
反应条件
1: methyl 2-amino-3-hydroxypropanoate hydrochloride With triethylamine in dichloromethane T=20°C; 0.5 h; 2: trityl chloride in dichloromethane T=20 - 30°C;
参考文献
ANACOR PHARMACEUTICALS, INC.; PLATTNER, Jacob, J.; LI, Xianfeng; HERNANDEZ, Vincent, S.
Patent: WO2014/7831 A1, 2014 ;
Location in patent: Paragraph 0100 ;
反应条件
triethylamine in dichloromethane T=20°C; 17.5 h;
参考文献
Li, Xianfeng; Plattner, Jacob J.; Hernandez, Vincent; Ding, Charles Z.; Wu, Wei; Yang, Yang; Xu, Musheng
Tetrahedron Letters, 2011 , vol. 52, # 38 p. 4924 - 4926
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=25°C; 24 h;
参考文献
Hernandez, O.; Chaudhary, S. K.; Cox, R. H.; Porter, J.
Tetrahedron Letters, 1981 , vol. 22, # 16 p. 1491 - 1494
反应条件
1: 95 percent / CH2Cl2 / 0.5 h / Ambient temperature 2: 60 percent / diisopropylethylamine / dimethylformamide / 24 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 22, # 16 p. 1491 - 1494
反应条件
1: 86 percent / Et3N, SO2Cl2 / toluene / -50 deg C, 1 h, 23 deg C, 16 h 2: 89 percent / diisobutylaluminum hydride / tetrahydrofuran / 23 h / 23 °C View Scheme
参考文献
Molander, Gary A.; Stengel, Peter J.
Tetrahedron, 1997 , vol. 53, # 26 p. 8887 - 8912
反应条件
methanesulfonyl chloride; triethylamine in tetrahydrofuran 1.) 20 deg C, 30 min, 2.) 66 deg C, 48 h;
参考文献
Willems, Johannes G. H.; Hersmis, Marco C.; De Gelder, Rene; Smits, Jan M. M.; Hammink, Jeannet B.; Dommerholt, F. Jan; Thijs, Lambertus; Zwanenburg, Binne
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 6 p. 963 - 967
反应条件
methyl 4-hydroxy-benzoate; triphenylphosphine; diethylazodicarboxylate in benzene 15 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 61, # 7 p. 2544 - 2546
反应条件
triphenylphosphine; diethylazodicarboxylate in benzene 15 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 61, # 7 p. 2544 - 2546
反应条件
sulfuryl dichloride; triethylamine in toluene -50 deg C, 1 h, 23 deg C, 16 h;
参考文献
Molander, Gary A.; Stengel, Peter J.
Tetrahedron, 1997 , vol. 53, # 26 p. 8887 - 8912
反应条件
1: 86 percent / Et3N, SO2Cl2 / toluene / -50 deg C, 1 h, 23 deg C, 16 h 2: 89 percent / diisobutylaluminum hydride / tetrahydrofuran / 23 h / 23 °C 3: 90 percent / Dess-Martin periodinane / pyridine; CH2Cl2 / 2 h / 23 °C View Scheme
参考文献
Molander, Gary A.; Stengel, Peter J.
Tetrahedron, 1997 , vol. 53, # 26 p. 8887 - 8912
