1-(2,3-二脱氧-3-氟-5-O-三苯甲基呋喃戊糖基)-5-甲基-2,4(1H,3H)-嘧啶二酮合成路线 （共 13 条）
反应条件
hydrogen fluoride; diethylaluminum fluoride in ethylene glycol dimethyl ether; n-heptane T=65°C; 4 h;
参考文献
Tetrahedron Letters, , vol. 32, # 19 p. 2091 - 2094
反应条件
hydrogen fluoride; tri-isopropylaluminum in ethylene glycol dimethyl ether; toluene T=65°C; 4 h;
参考文献
Green; Blum
Tetrahedron Letters, 1991 , vol. 32, # 19 p. 2091 - 2094
反应条件
potassium fluoride; 18-crown-6 ether in N,N-dimethyl-formamide T=100°C; 1 h;
参考文献
Wilson, I. K.; Chatterjee, S.; Wolf, W.
Journal of Fluorine Chemistry, 1991 , vol. 55, # 3 p. 283 - 289
反应条件
diethylamino-sulfur trifluoride in dichloromethane 1 h; Ambient temperature;
参考文献
Journal of Fluorine Chemistry, , vol. 55, # 3 p. 283 - 289
反应条件
1: pyridine 2: 17 percent / NaOH 3: DAST; pyridine / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 19 p. 2695 - 2698
反应条件
1: 17 percent / NaOH 2: DAST; pyridine / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 19 p. 2695 - 2698
反应条件
1: pyridine / 0.5 h / steam bath 2: 85 percent / pyridine / 32 h / Ambient temperature 3: 89 percent / NaOH / ethanol / 1 h / Heating 4: 86 percent / pyridine / 1.) 22 h, 2.) rt, 3 h 5: 57 percent / KF, 18-crown-6 ether / dimethylformamide / 1 h / 100 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 55, # 3 p. 283 - 289
反应条件
1: 89 percent / NaOH / ethanol / 1 h / Heating 2: 86 percent / pyridine / 1.) 22 h, 2.) rt, 3 h 3: 57 percent / KF, 18-crown-6 ether / dimethylformamide / 1 h / 100 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 55, # 3 p. 283 - 289
反应条件
1: pyridine / 0.5 h / steam bath 2: 85 percent / pyridine / 32 h / Ambient temperature 3: 89 percent / NaOH / ethanol / 1 h / Heating 4: 86 percent / pyridine / 1.) 22 h, 2.) rt, 3 h 5: 57 percent / KF, 18-crown-6 ether / dimethylformamide / 1 h / 100 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 55, # 3 p. 283 - 289
反应条件
1: 70 percent / aq. sodium hydroxide / ethanol / 4 h / Heating 2: N,N-dimethylaminopyridine / dimethylformamide / 4 h / 50 °C 3: diethylaminosulfurtrifluoride / CH2Cl2 / 0 - 25 °C View Scheme
参考文献
Nucleosides, Nucleotides and Nucleic Acids, , vol. 23, # 1-2 p. 7 - 29
