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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
1351987-19-3
合成路线
（共 5 条）
1351987-19-3
→
反应条件
172900-70-8
(R)-2-[3-(3-甲氧基丙氧基)-4-甲氧基苄基]-3-甲基丁-1-醇
反应条件
1.1: camphor-10-sulfonic acid / toluene / Dean-Stark system; Reflux 2.1: hydrogen / palladium 10 on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr 3.1: hydrogenchloride; tri-(hydroxymethyl)-methylamine; water; HLAP / 48 h / 40 °C / Enzymatic reaction 3.2: 20 °C / pH 3.5 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere 4.2: 20 °C View Scheme
参考文献
WO2011/151442 A2, ;
1351987-19-3
→
反应条件
172900-71-9
(ar)-4-甲氧基-3-(3-甲氧基丙氧基)-a-(1-甲基乙基)-苯丙酸
反应条件
1.1: camphor-10-sulfonic acid / toluene / Dean-Stark system; Reflux 2.1: hydrogen / palladium 10 on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr 3.1: hydrogenchloride; tri-(hydroxymethyl)-methylamine; water; HLAP / 48 h / 40 °C / Enzymatic reaction 3.2: 20 °C / pH 3.5 View Scheme
参考文献
CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo
Patent: WO2011/151442 A2, 2011 ;
1351987-19-3
→
反应条件
反应条件
1: camphor-10-sulfonic acid / toluene / |Reflux; |Dean-Stark 2: hydrogen; palladium 10 on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr 3: HLAP; water / aq. buffer / 48 h / 40 °C / pH 7.5 / |Enzymatic reaction View Scheme
参考文献
Chemo Iberica, S.A.; Taddei, Maurizio; Russo, Adele; Cini, Elena; Riva, Renata; Rasparini, Marcello; Carcone, Luca; Banfi, Luca; Vitale, Romina; Roseblade, Stephen; Zanotti-Gerosa, Antonio Carlo
Patent: US2013/71899 A1, 2013 ;
1351987-19-3
→
反应条件
866030-35-5
[(1S,3S)-3-[[4-甲氧基-3-(3-甲氧基丙氧基)苯基]甲基]-4-甲基-1-[(2S,4S)-四氢-4-异丙基-5-氧代-2-呋喃基]戊基]-氨基甲酸叔丁酯
反应条件
1.1: camphor-10-sulfonic acid / toluene / Dean-Stark system; Reflux 2.1: hydrogen / palladium 10 on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr 3.1: hydrogenchloride; tri-(hydroxymethyl)-methylamine; water; HLAP / 48 h / 40 °C / Enzymatic reaction 3.2: 20 °C / pH 3.5 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere 4.2: 20 °C 5.1: triethylamine / toluene / 1.5 h / 0 - 20 °C / Inert atmosphere 6.1: sodium iodide / acetonitrile / Inert atmosphere; Reflux 7.1: N,N-dimethyl acetamide / 24 h / 25 °C / Inert atmosphere 8.1: triethylamine / 4-(N,N-dimethlyamino)pyridine / 3 h / Inert atmosphere 9.1: trifluoroacetic acid / 1 h / 20 °C / Inert atmosphere 10.1: triethylamine; hydrogen / [Rh(S)-phanephos(cod)]BF4 / ethanol / 6 h / 60 °C / 22502.3 Torr / Autoclave 11.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 80 °C / Inert atmosphere 11.2: 8 h / 50 °C / Reflux 12.1: hydrogenchloride; water / ethanol / 48 h / 70 °C 13.1: hydrogen / palladium 10 on activated carbon / methanol / 12 h / 760.05 Torr 13.2: Inert atmosphere View Scheme
参考文献
CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo
Patent: WO2011/151442 A2, 2011 ;
1351987-19-3
→
反应条件
900811-38-3
(R)-[2-碘甲基-3-甲基丁基]-1-甲氧基-2-(3-甲氧基丙氧基)苯
反应条件
1.1: camphor-10-sulfonic acid / toluene / Dean-Stark system; Reflux 2.1: hydrogen / palladium 10 on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr 3.1: hydrogenchloride; tri-(hydroxymethyl)-methylamine; water; HLAP / 48 h / 40 °C / Enzymatic reaction 3.2: 20 °C / pH 3.5 4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere 4.2: 20 °C 5.1: triethylamine / toluene / 1.5 h / 0 - 20 °C / Inert atmosphere 6.1: sodium iodide / acetonitrile / Inert atmosphere; Reflux View Scheme
参考文献
Chemo Iberica, S.A.; Taddei, Maurizio; Russo, Adele; Cini, Elena; Riva, Renata; Rasparini, Marcello; Carcone, Luca; Banfi, Luca; Vitale, Romina; Roseblade, Stephen; Zanotti-Gerosa, Antonio Carlo
Patent: US2013/71899 A1, 2013 ;
