1: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 6 h / 25 °C 2: 53 percent / EDCI, HOBt*H2O / dimethylformamide / 12 h / 25 °C 3: aq. LiOH / tetrahydrofuran; methanol / 2 h / 25 °C 4: 3 N HCl / ethyl acetate / 1 h / 25 °C 5: 58 percent / NaHCO3, diphenyl phosphoroazidate (DPPA) / dimethylformamide / 72 h / 0 °C 6: 57 percent / BBr3 / CH2Cl2 / 3 h / -78 - 20 °C View Scheme

1: 98 percent / H2 / 10percent Pd/C / tetrahydrofuran / 6 h / 25 °C 2: 53 percent / EDCI, HOBt*H2O / dimethylformamide / 12 h / 25 °C 3: aq. LiOH / tetrahydrofuran; methanol / 2 h / 25 °C 4: 3 N HCl / ethyl acetate / 1 h / 25 °C 5: 58 percent / NaHCO3, diphenyl phosphoroazidate (DPPA) / dimethylformamide / 72 h / 0 °C View Scheme