反应条件
1.1: sodium hydroxide; water / tetrahydrofuran / 2.17 h / 40 °C
2.1: benzotriazol-1-ol; lithium hydroxide hydrate / water / 0.17 h
2.2: 4 h / 23 °C
2.3: pH 3
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -20 - 0 °C
4.1: sodium hydride / dichloromethane; N,N-dimethyl-formamide / 4 h / 23 °C
5.1: lithium hydroxide hydrate / tetrahydrofuran / 1.5 h / 35 °C
5.2: pH 4
6.1: diisopropyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 - 23 °C
7.1: hydrogen / 5 palladium on charcoal / methanol / 4 h / 65 °C / 7500.75 Torr
View Scheme
