3-环己烯氨基甲酸叔丁酯合成路线 （共 15 条）
反应条件
1: With triethylamine in dichloromethane
T=0°C; 0.833333 h; Inert atmosphere;
2: With potassium tert-butylate in tetrahydrofuran
T=20°C; 16 h; Inert atmosphere;
参考文献
Harty, Matthew; Nagar, Mitesh; Atkinson, Logan; Legay, Christina M.; Derksen, Darren J.; Bearne, Stephen L.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 390 - 393
反应条件
bis(tricyclohexylphosphine)benzylidene ruthenium(IV) dichloride in dichloromethane
T=23°C; 24 h;
参考文献
Maier, Martin E.; Lapeva, Tzvetelina
Synlett, 1998 , # 8 p. 891 - 893
反应条件
diphenyl phosphoryl azide; triethylamine
T=20 - 90°C; 49 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1577301 A1, 2005 ;
Location in patent: Page/Page column 138 ;
反应条件
triethylamine in tert-butyl alcohol
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1270557 A1, 2003 ;
反应条件
copper(l) chloride
T=80°C; 1 h; Reflux;
参考文献
NABRIVA THERAPEUTICS AG; RIEDL, Rosemarie; HEILMAYER, Werner; SPENCE, Lee
Patent: WO2011/146954 A1, 2011 ;
Location in patent: Page/Page column 57-58 ;
反应条件
1: With 1H-imidazole; iodine; triphenylphosphine in dichloromethane
T=20°C; Inert atmosphere;
2: With 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
18 h; Reflux;
参考文献
Alvarez-Perez, Monica; Marco-Contelles, Jose
Synthesis, 2009 , # 21 p. 3649 - 3653
反应条件
sodium azide; diphenyl phosphoryl azide; tetrakis(triphenylphosphine) palladium(0)
T=80°C; Rearrangement; Curtius rearrangement; Addition; 20 h;
参考文献
Okumoto, Hiroshi; Nishihara, Satoshi; Yamamoto, Sinya; Hino, Hirokazu; Nozawa, Akihiro; Suzuki, Akira
Synlett, 2000 , # 7 p. 991 - 992
反应条件
1: Et3N; diphenylphosphoryl azide / toluene / 3 h / Heating
2: 2.88 g / CuCl / toluene / 2 h / 100 °C
View Scheme
参考文献
Kapferer, Peter; Vasella, Andrea
Helvetica Chimica Acta, 2004 , vol. 87, # 11 p. 2764 - 2789
反应条件
1: 48 percent / BF3*Et2O / CH2Cl2 / 1.) 0-5 deg C, 30 min, 2.) r.t., 12 h
2: 91 percent / Grubbs catalyst / CH2Cl2 / 24 h / 23 °C
View Scheme
参考文献
Maier, Martin E.; Lapeva, Tzvetelina
Synlett, 1998 , # 8 p. 891 - 893
反应条件
1: 48 percent / BF3*Et2O / CH2Cl2 / 1.) 0-5 deg C, 30 min, 2.) r.t., 12 h
2: 91 percent / Grubbs catalyst / CH2Cl2 / 24 h / 23 °C
View Scheme
参考文献
Maier, Martin E.; Lapeva, Tzvetelina
Synlett, 1998 , # 8 p. 891 - 893
