1,2-双(氯二甲基硅基)乙烷合成路线 （共 41 条）
反应条件
hydrogenchloride in tetrahydrofuran; xylene T=20°C; 3 h; Heating / reflux;
参考文献
AMEDIS PHARMACEUTICALS LTD.
Patent: WO2004/45625 A1, 2004 ;
Location in patent: Page/Page column 17,18 ;
反应条件
in tetrahydrofuran T=20 - 95°C; 2 h;
参考文献
Toyama, Hirozumi; Nakamura, Masaharu; Nakamura, Masahiko; Matsumoto, Yotaro; Nakagomi, Madoka; Hashimoto, Yuichi
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 6 p. 1948 - 1959
反应条件
Ambient temperature;
参考文献
Kusumoto, Tetsuo; Hiyama, Tamejiro
Chemistry Letters, 1988 , p. 1149 - 1152
反应条件
triethylamine in dichloromethane
参考文献
Schering Aktiengesellschaft
Patent: US4971987 A1, 1990 ;
反应条件
triethylamine in dichloromethane
参考文献
Ciba-Geigy Corporation
Patent: US5068371 A1, 1991 ;
反应条件
Ph3SiLi; lithium in tetrahydrofuran
T=10°C; 5 h; Yield given. Yields of byproduct given;
参考文献
Ishikawa, Mitsuo; Yamanaka, Toru; Kumada, Makoto
Journal of Organometallic Chemistry, 1985 , vol. 292, p. 167 - 176
反应条件
Ph3SiLi; lithium in tetrahydrofuran
T=15°C; 10 h; Yield given. Yields of byproduct given;
参考文献
Ishikawa, Mitsuo; Yamanaka, Toru; Kumada, Makoto
Journal of Organometallic Chemistry, 1985 , vol. 292, p. 167 - 176
反应条件
1: 16 percent / lithium aluminum hydride / diethyl ether / 3 h / Heating
2: 1.) ethylmagnesium bromide / 1.) THF, 30 min, 5 deg C; 2.) THF, r.t.
3: 58.2 percent / chloroplatinic acid / propan-2-ol; cyclohexane / 1.) 2 h, reflux, 2.) r.t., overnight
View Scheme
参考文献
Steinmetz, Mark G.; Udayakumar, B. S.
Journal of Organometallic Chemistry, 1989 , vol. 378, p. 1 - 16
反应条件
ammonia in diethyl ether
参考文献
Hosomi, Akira; Kohra, Shinya; Tominaga, Yoshinori; Inaba, Masahiro; Sakurai, Hideki
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, p. 2342 - 2345
反应条件
ammonia in diethyl ether
T=-70°C;
参考文献
Herrmann, Wolfgang A.; Dyckhoff, Florian; Herdtweck, Eberhardt
Chemische Berichte, 1992 , vol. 125, # 12 p. 2651 - 2656
