4,6-二羟基吡嗪-3-羧酸乙酯合成路线 （共 2 条）
反应条件
trichlorophosphate T=95°C; 4 h;
参考文献
Xie, Linghong; Han, Bingsong; Xu, Yuelian; Maynard, George D.
Patent: US2004/77653 A1, 2004 ;
Location in patent: Page 18 ;
US 20040077653 A1
反应条件
1.1: triethylamine; 4-Acetylaminobenzenesulfonyl Azide / acetonitrile / 1 h / 0 - 25 °C
2.1: triphenylphosphine / diethyl ether / 20 - 25 °C
2.2: 6 h / 115 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; MOSLIN, Ryan M.; WEINSTEIN, David S.; WROBLESKI, Stephen T.; TOKARSKI, John S.; KUMAR, Amit
Patent: WO2014/74661 A1, 2014 ;
