in acetonitrile T=20 - 60°C; 48 h;

1.1: thiourea; potassium iodide / ethanol / 14 h / Reflux 1.2: 3 h / Reflux 2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C 3.1: N-Trimethylamine hydrochloride; triethylamine / dichloromethane / 1 h / 0 °C 4.1: acetonitrile / 48 h / 20 - 60 °C View Scheme

1: N-Trimethylamine hydrochloride; triethylamine / dichloromethane / 1 h / 0 °C 2: acetonitrile / 48 h / 20 - 60 °C View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 °C 2: N-Trimethylamine hydrochloride; triethylamine / dichloromethane / 1 h / 0 °C 3: acetonitrile / 48 h / 20 - 60 °C View Scheme

dihydrogen peroxide in tetrahydrofuran; water; acetic acid T=0 - 20°C; 2 h;