6-苯基吡嗪-2-羧酸甲酯合成路线 （共 4 条）
反应条件
triethylamine; N-ethyl-N,N-diisopropylamine; Pd(II) R-Binap T=100°C; P=3620.13 Torr; 18 h; Inert atmosphereSealed tube;
参考文献
NOVARTIS AG; BURGER, Matthew; DING, Yu; HAN, Wooseok; LINDVALL, Mika; NISHIGUCHI, Gisele A.; RICO, Alice; SMITH, Aaron; TANNER, Huw; WAN, Lifeng
Patent: WO2012/4217 A1, 2012 ;
Location in patent: Page/Page column 63-64 ;
WO 2012/004217 A1
反应条件
1: methyl pyrazine-2-carboxylate With trifluoroacetic acid in dichloromethane; water 0.25 h; 2: 3,4,5-trimethoxyphenylboronic acid With iron sulphate heptahydrate; dipotassium peroxodisulfate in dichloromethane; water T=20°C; 5 h; 3: With sodium hydroxide in dichloromethane; water T=20°C; Overall yield = 80 percent;
参考文献
Komeyama, Kimihiro; Nagao, Yuya; Abe, Manabu; Takaki, Ken
Bulletin of the Chemical Society of Japan, 2014 , vol. 87, # 2 p. 301 - 313
反应条件
1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / ethylene glycol dimethyl ether; water / 0.25 h / 120 °C / Microwave irradiation 2: triethylamine; N-ethyl-N,N-diisopropylamine / Pd(II) R-Binap / 18 h / 100 °C / 3620.13 Torr / Inert atmosphere; Sealed tube View Scheme
参考文献
Burger, Matthew; Ding, Yu; Han, Wooseok; Nishiguchi, Gisele; Rico, Alice; Simmons, Robert Lowell; Smith, Aaron R.; Tamez, JR., Victoriano; Tanner, Huw; Wan, Lifeng
Patent: US2012/225061 A1, 2012 ;
US 20120225061 A1
反应条件
1: With lithium hydroxide hydrate in tetrahydrofuran T=20°C; 48 h; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Burger, Matthew; Ding, Yu; Han, Wooseok; Nishiguchi, Gisele; Rico, Alice; Simmons, Robert Lowell; Smith, Aaron R.; Tamez, JR., Victoriano; Tanner, Huw; Wan, Lifeng
Patent: US2012/225061 A1, 2012 ;
Location in patent: Page/Page column 24 ;
US 20120225061 A1
