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乙二醇
甲醛
63148-62-9
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丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
5-溴-3-氨基吡啶
合成路线
（共 37 条）
13535-01-8
5-溴-3-氨基吡啶
→
反应条件
1083326-28-6
N-(5-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)吡啶-3-基)苯磺酰胺
反应条件
1: pyridine / dichloromethane / 20 °C / Inert atmosphere 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate / dichloromethane / 100 °C / Inert atmosphere View Scheme
参考文献
CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/238587 A1, 2012 ;
US 20120238587 A1
13535-01-8
5-溴-3-氨基吡啶
+
64-17-5
乙醇
→
反应条件
17117-17-8
5-溴-3-乙氧基吡啶
反应条件
dinitrogen trioxide
参考文献
Ukai
Yakugaku Zasshi, 1931 , vol. 51, p. 542,571; dtsch. Ref. S. 73, 76
Chem.Abstr., 1931 , p. 5427
13535-01-8
5-溴-3-氨基吡啶
+
591-50-4
碘苯
+
73183-34-3
联硼酸频那醇酯
→
反应条件
142137-17-5
3-溴-5-苯基吡啶
反应条件
1: 5 -Bromo -pyridin-3 -ylamine; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With tert.-butylnitrite in acetonitrile T=80°C; 2 h; 2: iodobenzene With tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide T=100°C; Suzuki-Miyaura Coupling; 12 h; Inert atmosphere;
参考文献
Qiu, Di; Jin, Liang; Zheng, Zhitong; Meng, He; Mo, Fanyang; Wang, Xi; Zhang, Yan; Wang, Jianbo
Journal of Organic Chemistry, 2013 , vol. 78, # 5 p. 1923 - 1933
13535-01-8
5-溴-3-氨基吡啶
+
56-81-5
甘油
→
反应条件
17965-71-8
3-溴-1,5-萘啶
反应条件
iron sulphate heptahydrate; sulfuric acid; boric acid; m-nitrobenzene sulfonic acid sodium salt in water T=135°C; Skraup Quinoline Synthesis; 18 h;
参考文献
ChemMedChem, , vol. 9, # 1 p. 217 - 232
13535-01-8
5-溴-3-氨基吡啶
→
反应条件
233770-01-9
3-溴-5-碘吡啶
反应条件
hydrogenchloride; potassium iodide; sodium nitrite Diazotization;
参考文献
Zwart; Wibaut
Recueil des Travaux Chimiques des Pays-Bas, 1955 , vol. 74, p. 1062,1068
13535-01-8
5-溴-3-氨基吡啶
+
67-64-1
丙酮
→
反应条件
1201643-57-3
5-溴-n-异丙基吡啶-3-胺
反应条件
1: With acetic acid in methanol pH=4; 0.5 h; 2: With methanol; sodium cyanoborohydride T=20°C;
参考文献
Samumed, LLC; Hood, John; Wallace, David Mark; Kumar KC, Sunil
Patent: US2013/267495 A1, 2013 ;
Location in patent: Paragraph 0444-0445 ;
13535-01-8
5-溴-3-氨基吡啶
+
802294-64-0
→
反应条件
1171897-14-5
反应条件
1: propionic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=20°C; 1 h; 2: 5 -Bromo -pyridin-3 -ylamine With 4-methyl-morpholine in N,N-dimethyl-formamide T=20°C; 18 h;
参考文献
Leblanc, Catherine; Pulz, Robert Alexander; Stiefl, Nikolaus Johannes
Patent: US2009/181941 A1, 2009 ;
Location in patent: Page/Page column 49 ;
13535-01-8
5-溴-3-氨基吡啶
+
10365-98-7
3-甲氧基苯硼酸
→
反应条件
1225523-08-9
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in methanol; water; toluene T=100°C; 40 h;
参考文献
Li, Guiying; Zhou, Hao; Jiang, Yu; Keim, Holger; Topiol, Sidney W.; Poda, Suresh B.; Ren, Yong; Chandrasena, Gamini; Doller, Dario
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1236 - 1242
13535-01-8
5-溴-3-氨基吡啶
+
5720-07-0
4-甲氧基苯硼酸
→
反应条件
1225522-97-3
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in water; N,N-dimethyl-formamide T=120°C; 0.166667 h; Inert atmosphereMicrowave irradiation;
参考文献
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; PINKERTON, Anthony, B.; DAHL, Russell; COSFORD, Nicholas, D.P.; MILLAN, Jose, Luis
Patent: WO2013/126608 A1, 2013 ;
Location in patent: Paragraph 00279 ;
13535-01-8
5-溴-3-氨基吡啶
+
124-63-0
甲烷磺酰氯
→
反应条件
1217273-00-1
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane 8 h; Inert atmosphere;
参考文献
Kim, Donghee; Jun, Hwiseok; Lee, Hyunseung; Hong, Soon-Sun; Hong, Sungwoo
Organic Letters, 2010 , vol. 12, # 6 p. 1212 - 1215
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