1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 1.2: 4 h / 70 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 2 h / 20 °C 3.1: sodium periodate / water; acetonitrile / 2 h / 20 °C 4.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 4.2: 2 h / 20 °C 5.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 6.1: hydrogenchloride; water / 3 h / 100 °C 7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 8.1: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 9.1: hydrogen bromide / water / 2 h / Reflux View Scheme

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 1.2: 4 h / 70 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 2 h / 20 °C 3.1: sodium periodate / water; acetonitrile / 2 h / 20 °C 4.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 4.2: 2 h / 20 °C 5.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 6.1: hydrogenchloride; water / 3 h / 100 °C 7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 8.1: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere View Scheme

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 1.2: 4 h / 70 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 2 h / 20 °C 3.1: sodium periodate / water; acetonitrile / 2 h / 20 °C 4.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 4.2: 2 h / 20 °C 5.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 6.1: hydrogenchloride; water / 3 h / 100 °C 7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 8.1: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 9.1: hydrogen bromide / water / 2 h / Reflux View Scheme

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 1.2: 4 h / 70 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 2 h / 20 °C 3.1: sodium periodate / water; acetonitrile / 2 h / 20 °C 4.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 4.2: 2 h / 20 °C 5.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 6.1: hydrogenchloride; water / 3 h / 100 °C 7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 8.1: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere View Scheme

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 1.2: 4 h / 70 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 2 h / 20 °C 3.1: sodium periodate / water; acetonitrile / 2 h / 20 °C 4.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 4.2: 2 h / 20 °C 5.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 6.1: hydrogenchloride; water / 3 h / 100 °C 7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 8.1: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 9.1: hydrogen bromide / water / 2 h / Reflux View Scheme

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere 1.2: 4 h / 70 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 2 h / 20 °C 3.1: sodium periodate / water; acetonitrile / 2 h / 20 °C 4.1: sodium dihydrogenphosphate / 2-methyl-but-2-ene; water; acetonitrile / 0.5 h 4.2: 2 h / 20 °C 5.1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C 6.1: hydrogenchloride; water / 3 h / 100 °C View Scheme