1: sodium methylate / methanol / 1 h / 0 °C 2: trichlorophosphate / Reflux 3: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 1 h / 0 °C 4: phosphorus tribromide / chloroform / 12 h / Reflux 5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 6: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 7: hydrogen bromide / water / 2 h / Reflux View Scheme

1: sodium methylate / methanol / 1 h / 0 °C 2: trichlorophosphate / Reflux 3: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 1 h / 0 °C 4: phosphorus tribromide / chloroform / 12 h / Reflux 5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C / Inert atmosphere 6: palladium diacetate; potassium carbonate; triphenylphosphine / toluene / 16 h / Reflux; Inert atmosphere 7: hydrogen bromide / water / 2 h / Reflux View Scheme