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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
1353991-68-0
合成路线
（共 5 条）
1353991-68-0
→
反应条件
205369-12-6
(R)-N-乙酰基-5-溴-3-(N-甲基吡咯烷-2-基甲基)-1H-吲哚
反应条件
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness 1.2: 0 - 35 °C / pH 12 - 13 2.1: N,N-dimethyl-formamide / 95 - 100 °C 2.2: 0 - 5 °C / pH 8 - 9 View Scheme
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar, Bhaskar; JOHAR, Perminder, Singh; SHARMA, Ekta; PRAJAPATY, Ramkaran; GUPTA, Chandan, Kumar
Patent: WO2012/4811 A1, 2012 ;
1353991-68-0
→
反应条件
143322-57-0
(R)-5-溴-3-(1-甲基-2-吡咯烷基甲基)-1H-吲哚
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in toluene T=10 - 50°C; Inert atmosphereDarkness; 2: With sodium hydroxide in water; toluene T=0 - 35°C; pH=12 - 13; Product distribution / selectivity;
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar, Bhaskar; JOHAR, Perminder, Singh; SHARMA, Ekta; PRAJAPATY, Ramkaran; GUPTA, Chandan, Kumar
Patent: WO2012/4811 A1, 2012 ;
Location in patent: Page/Page column 29-30 ;
1353991-68-0
→
反应条件
143322-58-1
依来曲普坦
反应条件
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness 1.2: 0 - 35 °C / pH 12 - 13 2.1: N,N-dimethyl-formamide / 95 - 100 °C 2.2: 0 - 5 °C / pH 8 - 9 3.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere 4.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C 5.1: hydrogen; methanesulfonic acid / 5 palladium on charcoal / acetone / 20 °C / 2585.81 Torr 5.2: 0.5 h / 25 - 30 °C View Scheme
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar, Bhaskar; JOHAR, Perminder, Singh; SHARMA, Ekta; PRAJAPATY, Ramkaran; GUPTA, Chandan, Kumar
Patent: WO2012/4811 A1, 2012 ;
1353991-68-0
→
反应条件
177834-92-3
依来曲普坦氢溴酸盐
反应条件
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness 1.2: 0 - 35 °C / pH 12 - 13 2.1: N,N-dimethyl-formamide / 95 - 100 °C 2.2: 0 - 5 °C / pH 8 - 9 3.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere 4.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C 5.1: hydrogen; methanesulfonic acid / 5 palladium on charcoal / acetone / 20 °C / 2585.81 Torr 5.2: 0.5 h / 25 - 30 °C 6.1: hydrogen bromide / dichloromethane; water; ethylene glycol / 0.5 h / 5 - 10 °C / Inert atmosphere View Scheme
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar, Bhaskar; JOHAR, Perminder, Singh; SHARMA, Ekta; PRAJAPATY, Ramkaran; GUPTA, Chandan, Kumar
Patent: WO2012/4811 A1, 2012 ;
1353991-68-0
→
反应条件
180637-89-2
(R)-3-[(1-甲基-2-吡咯烷基)甲基]-5-[2-(苯磺酰基)乙烯基]-1H-吲哚
反应条件
1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness 1.2: 0 - 35 °C / pH 12 - 13 2.1: N,N-dimethyl-formamide / 95 - 100 °C 2.2: 0 - 5 °C / pH 8 - 9 3.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 90 - 95 °C / Inert atmosphere 4.1: water; sodium carbonate; methanol / 2 h / 25 - 30 °C View Scheme
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar, Bhaskar; JOHAR, Perminder, Singh; SHARMA, Ekta; PRAJAPATY, Ramkaran; GUPTA, Chandan, Kumar
Patent: WO2012/4811 A1, 2012 ;
