(1R,2S,3S,5S)-3-(4-碘苯基)-8-甲基-8-氮杂双环[3.2.1]辛烷-2-羧酸甲酯合成路线 (共 14 条)
反应条件
1.1: α-chloroethyl chloroformate / 1,2-dichloro-ethane / Heating 1.2: MeOH / 20 °C 2.1: KI; Et3N / ethanol / Heating View Scheme
参考文献
Gu, Xiao-Hui; Zong, Rushi; Kula, Nora S.; Baldessarini, Ross J.; Neumeyer, John L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 23 p. 3049 - 3053
反应条件
peracetic acid; 123I sodium iodide; tetrakis(triphenylphosphate)palladium(0); palladium diacetate; 1,1,1,2,2,2-hexabutyl-distannane
1.) THF, reflux; Yield given. Multistep reaction;
参考文献
Neumeyer; Wang; Milius; Baldwin; Zea-Ponce; Hoffer; Sybirska; Al-Tikriti; Charney; Malison; Laruelle; Innis
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 3144 - 3146
反应条件
1: With 1-chloroethyl chlorocarbonate in dichloromethane
Heating;
2: With methanol
Heating;
参考文献
Tamagnan, Gilles; Alagille, David; Fu, Xing; Kula, Nora S.; Baldessarini, Ross J.; Innis, Robert B.; Baldwin, Ronald M.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1131 - 1133
反应条件
1: 90 percent / H2O / dioxane / 24 h / Heating
2: POCl3
3: Et3N / CH2Cl2
View Scheme
参考文献
Gu, Xiao-Hui; Zong, Rushi; Kula, Nora S.; Baldessarini, Ross J.; Neumeyer, John L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 23 p. 3049 - 3053