(2-硝基-4-三氟甲基苯基)乙酸甲酯合成路线 （共 8 条）
反应条件
sodium chloride in water; dimethyl sulfoxide T=120°C; 16 - 20 h;
参考文献
Georg, Gunda I.; Tash, Joseph S.; Chakrasali, Ramappa; Jakkaraj, Sudhakar Rao
Patent: US2006/47126 A1, 2006 ;
Location in patent: Page/Page column 26 ;
反应条件
sulfuric acid T=65°C; 1.5 h;
参考文献
MERCK PATENT GMBH
Patent: WO2005/75425 A2, 2005 ;
Location in patent: Page/Page column 230 ;
WO 2005/075425 A2
反应条件
1: K2CO3 / dimethylformamide 2: H2SO4 / aq. acetic acid 3: H2SO4 View Scheme
参考文献
Israel Journal of Chemistry, , vol. 4, p. 155 - 159
反应条件
1: H2SO4 / aq. acetic acid 2: H2SO4 View Scheme
参考文献
Israel Journal of Chemistry, , vol. 4, p. 155 - 159
反应条件
1: HNO3, H2SO4 2: K2CO3 / dimethylformamide 3: H2SO4 / aq. acetic acid 4: H2SO4 View Scheme
参考文献
Israel Journal of Chemistry, , vol. 4, p. 155 - 159
反应条件
hydrogen; 5-palladium/activated carbon in tetrahydrofuran T=20°C;
参考文献
MERCK PATENT GMBH
Patent: WO2005/75425 A2, 2005 ;
Location in patent: Page/Page column 230 ;
WO 2005/075425 A2
参考文献
Sugen, Inc.
Patent: US6878733 B1, 2005 ;
Location in patent: Page/Page column 171 ;
US 6878733 B1
反应条件
1: hydrogen / 5 Pd(II)/C(eggshell) / toluene / 20 °C / 760.05 Torr
2: tert.-butylnitrite; acetic acid / 2.17 h / 90 - 95 °C / Cooling with ice
View Scheme
参考文献
UNIVERSITY OF KANSAS; GEORGE, Ingrid, Gunda; TASH, Joseph, S.; CHAKRSALI, Ramappa; JAKKARAJ, Sudhakar, R.; CALVET, James, P.
Patent: WO2011/5759 A2, 2011 ;
