1-[6-(羟基甲基)-2-吡啶]乙酮合成路线 （共 7 条）
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 0.666667 h;
参考文献
WO2005/12323 A2, ;
Page/Page column 49 ;
WO 2005/012323 A2
反应条件
1: With sodium ethanolate in toluene 5 h; Heating; 2: With sulfuric acid 2 h; Heating; Further stages.;
参考文献
Synthetic Communications, , vol. 37, # 19 p. 3393 - 3402
反应条件
in tetrahydrofuran; diethyl ether T=0 - 5°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 1 p. 57 - 66
反应条件
1.1: 48 percent / sodium borohydride / methanol / 5 h / Heating 2.1: EtONa / toluene / 5 h / Heating 2.2: 46 percent / aq. H2SO4 / 2 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 37, # 19 p. 3393 - 3402
反应条件
1.1: 79 percent / H2SO4 / 24 h / Heating 2.1: 48 percent / sodium borohydride / methanol / 5 h / Heating 3.1: EtONa / toluene / 5 h / Heating 3.2: 46 percent / aq. H2SO4 / 2 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 37, # 19 p. 3393 - 3402
反应条件
trichlorophosphate in DMF (N,N-dimethyl-formamide) T=0°C; 3 h;
参考文献
Flentge, Charles A.; Chen, Hui-Ju; DeGoey, David A.; Flosi, William J.; Grampovnik, David J.; Huang, Peggy P.; Kempf, Dale J.; Klein, Larry L.; Krueger, Allan C.; Madigan, Darold L.; Randolph, John T.; Sun, Minghua; Yeung, Ming C.; Zhao, Chen
Patent: US2011/3827 A1, 2011 ;
Location in patent: Page/Page column 113 ;
US 20110003827 A1
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=0°C; 0.333333 h;
参考文献
TRIGEN LIMITED
Patent: WO2005/12323 A2, 2005 ;
Location in patent: Page/Page column 48-49 ;
WO 2005/012323 A2
