6-苯甲基-5,6,7,8-四氢-1H-哌啶并[4,3-D]2,4-二嘧啶酮合成路线 （共 13 条）
反应条件
1.1: trichlorophosphate / 3 h / |Inert atmosphere 2.1: 2-chloroethoxycarbonyl chloride / dichloromethane / 1.25 h / 0 - 20 °C 2.2: 0.5 h / |Reflux 3.1: tetraalkylammonium carbonate polymer-bound resin / dichloromethane / 1 h / 20 °C View Scheme
参考文献
ZHOU, Han-Jie; PARLATI, Francesco; WUSTROW, David
Patent: WO2014/15291 A1, 2014 ;
反应条件
1: trichlorophosphate / 2 h / 100 °C 2: 1-chloroethyl chlorocarbonate / 1,2-dichloro-ethane / 6 h / 0 - 100 °C View Scheme
参考文献
ZHOU, Han-Jie; PARLATI, Francesco; WUSTROW, David
Patent: WO2014/15291 A1, 2014 ;
反应条件
1.1: trichlorophosphate / 3 h / |Inert atmosphere 2.1: 2-chloroethoxycarbonyl chloride / dichloromethane / 1.25 h / 0 - 20 °C 2.2: 0.5 h / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 24 p. 10958 - 10971
