5-氯-1,3-二甲基-4-硝基-1H-吡唑合成路线 （共 7 条）
反应条件
PPA; nitric acid T=85°C; 3 h;
参考文献
Bozhenkov; Savosik; Larina; Mirskova; Levkovskaya
Russian Journal of Organic Chemistry, 2006 , vol. 42, # 6 p. 901 - 906
反应条件
hydrogenchloride diazotation;
参考文献
Perevalov, V. P.; Baryshnenkova, L. I.; Denisova, E. A.; Andreeva, M. A.; Stepanov, B. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 12 p. 1397
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , # 12 p. 1691 - 1692
反应条件
dibenzoyl peroxide in tetrachloromethane; hexane; dichloromethane
参考文献
Cell Pathways, Inc.
Patent: US6200980 B1, 2001 ;
反应条件
bromine in tetrachloromethane 96 h; HeatingIrradiation;
参考文献
Fray, M. Jonathan; Bull, David J.; Cooper, Kelvin; Parry, M. John; Stefaniak, Mark H.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3524 - 3535
反应条件
potassium iodide in ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile
参考文献
Warner-Lambert Company
Patent: US4666908 A1, 1987 ;
反应条件
potassium iodide in N,N-dimethyl-formamide; acetonitrile 22 h; Heating;
参考文献
Hamilton, Harriet W.; Ortwine, Daniel F.; Worth, Donald F.; Bristol, James A.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 91 - 96
反应条件
hydrazine hydrate in ethanol
2 h; Heating;
参考文献
Abu Safieh, Kayed A.; Abu Mahthieh, Ahmad M.; El-Abadelah, Mustafa M.; Ayoub, Mikdad T.; Voelter, Wolfgang
Monatshefte fur Chemie, 2007 , vol. 138, # 2 p. 157 - 160
