乙基4-(甲氧基甲基)-6-丙氧基-9H-吡啶并[5,4-b]吲哚-3-羧酸酯合成路线 （共 6 条）
反应条件
1: 98 percent / K2CO3 / acetone / Heating 2: 95 percent / glacial acetic acid / toluene / 1.25 h / Heating 3: 79 percent / H2 / Raney nickel / ethanol / 36 h 4: 90 percent / 10percent aq. K2CO3 / ethyl acetate / 16 h / Ambient temperature 5: xylene / 1 h / Heating 6: sulfur / dimethylsulfoxide / 1.5 h / 144 °C View Scheme
参考文献
Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552
反应条件
1: 95 percent / glacial acetic acid / toluene / 1.25 h / Heating 2: 79 percent / H2 / Raney nickel / ethanol / 36 h 3: 90 percent / 10percent aq. K2CO3 / ethyl acetate / 16 h / Ambient temperature 4: xylene / 1 h / Heating 5: sulfur / dimethylsulfoxide / 1.5 h / 144 °C View Scheme
参考文献
Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552
反应条件
1: 90 percent / NH4OCOH / 10percent Pd/C / ethanol / Ambient temperature 2: 98 percent / K2CO3 / acetone / Heating 3: 95 percent / glacial acetic acid / toluene / 1.25 h / Heating 4: 79 percent / H2 / Raney nickel / ethanol / 36 h 5: 90 percent / 10percent aq. K2CO3 / ethyl acetate / 16 h / Ambient temperature 6: xylene / 1 h / Heating 7: sulfur / dimethylsulfoxide / 1.5 h / 144 °C View Scheme
参考文献
Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552
反应条件
1: 79 percent / H2 / Raney nickel / ethanol / 36 h 2: 90 percent / 10percent aq. K2CO3 / ethyl acetate / 16 h / Ambient temperature 3: xylene / 1 h / Heating 4: sulfur / dimethylsulfoxide / 1.5 h / 144 °C View Scheme
参考文献
Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552
反应条件
1: 90 percent / 10percent aq. K2CO3 / ethyl acetate / 16 h / Ambient temperature 2: xylene / 1 h / Heating 3: sulfur / dimethylsulfoxide / 1.5 h / 144 °C View Scheme
参考文献
Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552
反应条件
1: xylene / 1 h / Heating 2: sulfur / dimethylsulfoxide / 1.5 h / 144 °C View Scheme
参考文献
Cox, Eric D.; Diaz-Arauzo, Hernando; Huang, Qi; Reddy, Mundla S.; Ma, Chunrong; Harris, Brad; McKernan, Ruth; Skolnick, Phil; Cook, James M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2537 - 2552
