2-氯-5-氟苯并[d]噁唑合成路线 （共 5 条）
反应条件
1: With phosphorus pentachloride; trichlorophosphate in dichloromethane T=20°C; 24 h; 2: With sodium hydroxide in water Cooling;
参考文献
GALLEON PHARMACEUTICALS, INC.
Patent: WO2009/151744 A1, 2009 ;
Location in patent: Page/Page column 118 ;
反应条件
phosphorus pentachloride in dichloromethane; trichlorophosphate
参考文献
PHARMACIA and UPJOHN COMPANY
Patent: EP883611 B1, 2002 ;
反应条件
1: ethanol 2: SOCl2; DMF / toluene View Scheme
参考文献
Lazer, Edward S.; Miao, Clara K.; Wong, Hin-Chor; Sorcek, Ronald; Spero, Denice M.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 7 p. 913 - 923
反应条件
phosphorus pentachloride in trichlorophosphate
参考文献
Pharmacia and Upjohn Company
Patent: US5736545 A1, 1998 ;
反应条件
1: hydrazine hydrate / dioxane / 0.5 h / Ambient temperature
2: 2 N sodium hydroxide / tetrahydrofuran / 1.) 60 deg C, 15 min, 2.) room temperature, 15 min
View Scheme
参考文献
Haviv; Ratajczyk; DeNet; Kerdesky; Walters; Schmidt; Holms; Young; Carter
Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1719 - 1728
