in acetonitrile T=90°C; pH=7; aq. phosphate buffer;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: 24 h / 160 &deg;C<br />1.2: Saturated solution<br />2.1: triethylamine / tetrahydrofuran / 1.5 h / 66 &deg;C / Microwave irradiation<br />3.1: N,N,N',N'-tetramethylguanidine / acetonitrile / 2 h / 5 &deg;C<br /> <br /> &nbsp;