Amberlyst A-15 in water; acetone T=80°C; 5 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11460447', constants.ctx, '0')">lithium aluminium tetrahydride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=0&deg;C;&nbsp;1.5&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 63 percent / NaNO₂ / dimethylformamide / 6 h<br />2: 2) Amberlyst A-21 / 1) 5 min, ice bath, 2) 7 h, rt<br />3: K₂Cr₂O₇, Bu₄NHSO₄, 30percent H₂SO₄ / CH₂Cl₂ / 2 h / -10 &deg;C<br />4: 90 percent / methanol / 12 h<br />5: 90 percent / LiALH₄ / tetrahydrofuran / 1.5 h / 0 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 2) Amberlyst A-21 / 1) 5 min, ice bath, 2) 7 h, rt<br />2: K₂Cr₂O₇, Bu₄NHSO₄, 30percent H₂SO₄ / CH₂Cl₂ / 2 h / -10 &deg;C<br />3: 90 percent / methanol / 12 h<br />4: 90 percent / LiALH₄ / tetrahydrofuran / 1.5 h / 0 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 90 percent / methanol / 12 h<br />2: 90 percent / LiALH₄ / tetrahydrofuran / 1.5 h / 0 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 2) Amberlyst A-21 / 1) 5 min, ice bath, 2) 7 h, rt<br />2: K₂Cr₂O₇, Bu₄NHSO₄, 30percent H₂SO₄ / CH₂Cl₂ / 2 h / -10 &deg;C<br />3: 90 percent / methanol / 12 h<br />4: 90 percent / LiALH₄ / tetrahydrofuran / 1.5 h / 0 &deg;C<br /> <br /> &nbsp;